汇总资源开放获取肌萎缩侧索硬化症临床试验数据库中体位性低血压的发生率。
Frequency of orthostatic hypotension in the Pooled Resource Open-Access ALS Clinical Trials database.
作者信息
Quarracino C, Capani F, Otero-Losada M, Rodríguez G E, Pérez-Lloret S
机构信息
Centro de Altos Estudios en Ciencias Humanas y de la Salud, Universidad Abierta Interamericana, Consejo Nacional de Investigaciones Científicas y Técnicas, CAECIHS, UAI-CONICET, Buenos Aires, Argentina.
Instituto de Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Santiago, Chile.
出版信息
Front Neurol. 2025 Jan 16;16:1512357. doi: 10.3389/fneur.2025.1512357. eCollection 2025.
PURPOSE
To explore the frequency of orthostatic hypotension (OH) in a large sample of amyotrophic lateral sclerosis patients (ALS).
METHODS
From the PRO-ACT database, data of 1,240 ALS patients were analyzed, focusing on blood pressure and heart rate before and after standing. OH was defined as a drop in systolic/diastolic blood pressure > 20/10 mm Hg within 3 min of standing. Neurogenic OH was diagnosed when the heart rate increase was below 15 bpm in patients not taking medications that could affect this response.
RESULTS
At baseline, 138 (11.1%) patients showed OH, 76.1% of whom had neurogenic OH. At follow-up, 163 patients (13.1%) had OH, 71.2% with neurogenic OH. Only 22.5% of the patients with OH at baseline had OH at follow-up.
CONCLUSION
In a large sample of ALS patients, OH occurred in 11-13%, pointing to a subgroup that might require special care to avoid related complications.
目的
探讨大量肌萎缩侧索硬化症（ALS）患者中体位性低血压（OH）的发生率。
方法
分析来自PRO-ACT数据库的1240例ALS患者的数据，重点关注站立前后的血压和心率。OH定义为站立3分钟内收缩压/舒张压下降>20/10 mmHg。在未服用可能影响此反应的药物的患者中，当心率增加低于15次/分钟时，诊断为神经源性OH。
结果
基线时，138例（11.1%）患者出现OH，其中76.1%为神经源性OH。随访时，163例（13.1%）患者出现OH，71.2%为神经源性OH。基线时出现OH的患者中，只有22.5%在随访时仍有OH。
结论
在大量ALS患者中，OH的发生率为11%-13%，提示这一亚组患者可能需要特别护理以避免相关并发症。
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