Voulaz Emanuele, Giudici Veronica Maria, Lanza Ezio, Bottoni Edoardo, Cariboni Umberto, Crepaldi Alessandro, Ferrillo Giuseppe, Marulli Giuseppe, Alloisio Marco, Mangiameli Giuseppe, Testori Alberto
Division of Thoracic Surgery, IRCCS Humanitas Research Hospital, Via Manzoni 56 Rozzano, 20089 Milan, Italy.
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4 Pieve Emanuele, 20090 Milan, Italy.
J Clin Med. 2023 Sep 23;12(19):6149. doi: 10.3390/jcm12196149.
The identification of small lung nodules is challenging during mini-invasive thoracic surgery. Unable to palpate them directly, surgeons have developed several methods to preoperatively localize pulmonary nodules, including the computed tomography-guided positioning of coils or metallic landmarks (hook wire) or bronchoscopic marking.
We present a series of patients scheduled for the video-assisted thoracoscopic sublobar resection of small pulmonary nodules, in which we performed preoperative percutaneous computed tomography (CT)-guided nodule localization through the injection of a mixture of indocyanine green and human albumin.
A total of 40 patients underwent a preoperative CT-guided injection of indocyanine green followed by VATS resection within 24 h. Patients tolerated the procedure well, no pain medication was administrated, and no complications were observed during the marking procedure. All pulmonary nodules were easily detected and successfully resected.
the near-infrared dye marking solution of indocyanine green (ICG) with diluted human albumin was safe, effective, and easy to perform. The ICG solution has the potential to facilitate the accurate localization and resection of pulmonary nodules during VATS surgery, avoiding the risk of marker displacement/migration.
在微创胸外科手术中，识别小肺结节具有挑战性。由于无法直接触诊，外科医生已开发出多种术前定位肺结节的方法，包括计算机断层扫描引导下的线圈或金属标志物（钩丝）定位或支气管镜标记。
我们报告了一系列计划进行电视辅助胸腔镜下小肺结节亚肺叶切除的患者，我们通过注射吲哚菁绿和人白蛋白的混合物进行术前经皮计算机断层扫描（CT）引导下的结节定位。
共有40例患者在术前接受了CT引导下的吲哚菁绿注射，并在24小时内接受了电视辅助胸腔镜手术切除。患者对该操作耐受性良好，未使用止痛药物，在标记过程中未观察到并发症。所有肺结节均易于检测并成功切除。
吲哚菁绿（ICG）与稀释的人白蛋白的近红外染料标记溶液安全、有效且易于操作。ICG溶液有可能在电视辅助胸腔镜手术期间促进肺结节的准确定位和切除，避免标志物移位/迁移的风险。
