Giers Johanna, Bartel Alexander, Kirsch Katharina, Müller Simon Franz, Horstmann Stephanie, Gehlen Heidrun
Equine Clinic, Internal Medicine, Freie Universität Berlin, Oertzenweg 19b, 14193 Berlin, Germany.
Institute for Veterinary Epidemiology and Biostatistics, Freie Universität Berlin, Königsweg 67, 14163 Berlin, Germany.
Animals (Basel). 2023 Oct 5;13(19):3110. doi: 10.3390/ani13193110.
Horses competing in cross-country tests are subjected to high physical demands. Within the scope of this prospective longitudinal study, blood values of 20 elite eventing horses were examined before and after two- to four-star cross-country rides. The aim was to find out whether blood-based markers for skeletal muscle and cardiac muscle function change after cross-country exercise. Parameters that provide information about fluid balance, muscle enzymes, metabolites and cardiac muscle-specific markers were investigated. We developed an approach to eliminate the concentration changes caused by reduced plasma volume. Parameters were measured pre, 10 and 30 min post exercise and the next morning and were evaluated using a mixed model. Thirty minutes after exercise, most parameter concentrations changed in an exercise-dependent manner. The next morning, most exercise-related markers recovered rapidly, while creatine kinase (CK) (26% increase; = 0.008) and lactate dehydrogenase (LDH) (15% increase; < 0.001) showed a declining but sustained increase. Cardiac troponin I (cTnI) increased above the reference range in 40 of the 55 rides (73%) and in 18 of 20 horses in the morning after exercise.
参加越野测试的马匹面临着很高的体能要求。在这项前瞻性纵向研究中，对20匹精英三项赛马匹在二星级至四星级越野骑行前后的血液值进行了检测。目的是了解越野运动后骨骼肌和心肌功能的血液标志物是否发生变化。研究了有关体液平衡、肌肉酶、代谢物和心肌特异性标志物的参数。我们开发了一种方法来消除血浆量减少引起的浓度变化。在运动前、运动后10分钟和30分钟以及第二天早晨测量参数，并使用混合模型进行评估。运动30分钟后，大多数参数浓度以与运动相关的方式发生变化。第二天早晨，大多数与运动相关的标志物迅速恢复，而肌酸激酶（CK）（增加26%；P = 0.008）和乳酸脱氢酶（LDH）（增加15%；P < 0.001）显示出下降但持续的增加。在55次骑行中的40次（73%）以及运动后早晨20匹马中的18匹马中，心肌肌钙蛋白I（cTnI）升高至参考范围以上。
