Hacker Sebastian, Reichel Thomas, Hecksteden Anne, Weyh Christopher, Gebhardt Kristina, Pfeiffer Mark, Ferrauti Alexander, Kellmann Michael, Meyer Tim, Krüger Karsten
Department of Exercise Physiology and Sports Therapy, Institute of Sport Science, Justus-Liebig-University Gießen, 35394 Gießen, Germany.
Institute of Sports and Preventive Medicine, Saarland University, 66123 Saarbrücken, Germany.
Int J Environ Res Public Health. 2021 May 27;18(11):5776. doi: 10.3390/ijerph18115776.
The purpose of this study was to investigate blood-based biomarkers and their regulation with regard to different recovery-stress states. A total of 35 male elite athletes (13 badminton, 22 soccer players) were recruited, and two venous blood samples were taken: one in a 'recovered' state (REC) after a minimum of one-day rest from exercise and another one in a 'non-recovered' state (NOR) after a habitual loading microcycle. Overall, 23 blood-based biomarkers of different physiologic domains, which address inflammation, muscle damage, and tissue repair, were analyzed by Luminex assays. Across all athletes, only creatine kinase (CK), interleukin (IL-) 6, and IL-17A showed higher concentrations at NOR compared to REC time points. In badminton players, higher levels of CK and IL-17A at NOR were found. In contrast, a higher value for S100 calcium-binding protein A8 (S100A8) at REC was found in badminton players. Similar differences were found for BDNF in soccer players. Soccer players also showed increased levels of CK, and IL-6 at NOR compared to REC state. Several molecular markers were shown to be responsive to differing recovery-stress states, but their suitability as biomarkers in training must be further validated.
本研究的目的是调查基于血液的生物标志物及其在不同恢复-应激状态下的调节情况。共招募了35名男性精英运动员（13名羽毛球运动员，22名足球运动员），并采集了两份静脉血样本：一份是在至少一天不运动后的“恢复”状态（REC）下采集的，另一份是在习惯性负荷微周期后的“未恢复”状态（NOR）下采集的。总体而言，通过Luminex检测分析了23种不同生理领域的基于血液的生物标志物，这些标志物涉及炎症、肌肉损伤和组织修复。在所有运动员中，与REC时间点相比，只有肌酸激酶（CK）、白细胞介素（IL-）6和IL-17A在NOR时浓度更高。在羽毛球运动员中，发现NOR时CK和IL-17A水平更高。相比之下，羽毛球运动员在REC时S100钙结合蛋白A8（S100A8）的值更高。足球运动员的脑源性神经营养因子（BDNF）也有类似差异。与REC状态相比，足球运动员在NOR时CK和IL-6水平也有所升高。几种分子标志物显示出对不同恢复-应激状态有反应，但其作为训练中生物标志物的适用性必须进一步验证。
