Lejczak B, Kafarski P, Sztajer H, Mastalerz P
J Med Chem. 1986 Nov;29(11):2212-7. doi: 10.1021/jm00161a014.
A series of dipeptides containing N-terminal alanine or leucine and a wide range of P-terminal racemic 1-amino-alkanephosphonates were prepared and tested in vitro for their ability to inhibit the growth of various bacterial species. The results demonstrate that peptides containing 4-amino-4-phosphonobutyric acid and 1-amino-1-methylethanephosphonic acid exhibit antibacterial activity comparable with that observed in the case of peptides containing P-terminal racemic 1-aminoethanephosphonic acid (analogue of alanine) used as a positive control.
制备了一系列N端为丙氨酸或亮氨酸且P端为多种外消旋1-氨基链烷膦酸酯的二肽，并在体外测试了它们抑制各种细菌生长的能力。结果表明，含有4-氨基-4-膦酰基丁酸和1-氨基-1-甲基乙烷膦酸的肽表现出的抗菌活性与以P端外消旋1-氨基乙烷膦酸（丙氨酸类似物）作为阳性对照的肽所观察到的抗菌活性相当。
