使用廉价手性催化剂 1,1'-联萘酚磷酸酯进行 alpha-氨基膦酸酯的不对称合成。
Asymmetric synthesis of alpha-aminophosphonates using the inexpensive chiral catalyst 1,1'-binaphthol phosphate.
机构信息
State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China.
出版信息
Molecules. 2010 Aug 24;15(8):5782-96. doi: 10.3390/molecules15085782.
Abstract
Asymmetric addition under mild conditions of dialkyl phosphites on aldimines derived from cinnamaldehyde catalyzed by the inexpensive chiral organocatalyst (R)-3,3'-4-fluorophenyl-1,1'-binaphthol phosphate has been found effective to give new alpha-amino-phosphonates 9 in moderate yields (30-65%) and enantiomeric excess (8.4%-61.9%).
摘要
在廉价手性有机催化剂（R）-3,3'-[4-氟苯基]（2）-1,1'-联萘酚磷酸酯的催化下，二烷基膦酸酯在肉桂醛衍生的亚胺的不对称加成反应在温和条件下已被发现是有效的，可得到新的α-氨基膦酸酯 9，中等收率（30-65%）和对映过量（8.4%-61.9%）。
Zotero 插件