用于基因排除分析的模型系统：囊性纤维化与19号染色体
A model system for the analysis of gene exclusion: cystic fibrosis and chromosome 19.
作者信息
Wainwright B, Farrall M, Watson E, Williamson R
出版信息
J Med Genet. 1986 Oct;23(5):417-20. doi: 10.1136/jmg.23.5.417.
Abstract
We have used multilocus analysis to exclude the cystic fibrosis locus from six polymorphic DNA markers covering most of chromosome 19. A substantial increase in the confidence for exclusion was obtained using the computer programme LINKAGE compared to analysis of pairwise lod scores. A structured approach to the analysis of linkage to autosomal recessive inherited diseases where the biochemical defect is not known is described.
摘要
我们已使用多位点分析，从覆盖19号染色体大部分区域的六个多态性DNA标记中排除囊性纤维化基因座。与分析成对的连锁不平衡分数相比，使用计算机程序LINKAGE可显著提高排除的可信度。本文描述了一种分析与常染色体隐性遗传疾病连锁关系的结构化方法，这些疾病的生化缺陷尚不清楚。
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