Centre de Recherche de Gif-sur-Yvette, Institut de Chimie des Substances Naturelles, UPR 2301, CNRS, Avenue de la Terrasse, 91198 Gif-sur-Yvette, France.
J Nat Prod. 2010 Apr 23;73(4):720-3. doi: 10.1021/np900539j.
The study of the n-butanol extract of the New Caledonian sponge Agelas dendromorpha led to the isolation and identification of three new pyrrole-2-aminoimidazole (P-2-AI) alkaloids, named agelastatins E (3) and F (4) and benzosceptrin C (5), together with 10 known metabolites, agelastatin A (1), agelastatin D (2), sceptrin (6), manzacidin A, tauroacidin A, taurodispacamide A, nortopsentin D, thymine, longamide, and 4,5-dibromopyrrole-2-carboxamide. Their structures were assigned by spectroscopic data interpretation. All the compounds were tested for cytotoxic activity.
研究表明，新喀里多尼亚海绵 Agelas dendromorpha 的正丁醇提取物中分离鉴定出了三种新的吡咯-2-氨基咪唑（P-2-AI）生物碱，分别命名为 agelastatin E（3）、agelastatin F（4）和 benzosceptrin C（5），此外还发现了 10 种已知代谢产物，包括 agelastatin A（1）、agelastatin D（2）、sceptrin（6）、manzacidin A、tauroacidin A、taurodispacamide A、nortopsentin D、胸腺嘧啶、longamide 和 4,5-二溴吡咯-2-甲酰胺。这些化合物的结构是通过光谱数据分析确定的。所有化合物均进行了细胞毒性活性测试。
