Liu Yuguang, Wu Ziqi
Department of Stomatology, The First Hospital of Jilin University, Changchun, 130021, China.
Saudi Dent J. 2025 Jul 15;37(4-6):29. doi: 10.1007/s44445-025-00036-9.
This narrative review systematically examines the emerging role of natural bioactive substances in dental tissue biomineralization. Through comprehensive analysis of peer-reviewed literature (2000-2024) identified via PubMed, Web of Science, and Scopus using keywords including 'natural drugs,' 'biomineralization,' and 'dental restoration,' we evaluate three key aspects: (1) the limitations of current restorative materials (composite resins, adhesives); (2) the mechanisms of natural compounds (collagen protection, mineral deposition, demineralization inhibition); and (3) clinical translation challenges. Our analysis reveals that plant-derived flavonoids, polyphenols, and bioactive peptides show particular promise for enhancing remineralization while addressing toxicity concerns. The review concludes by proposing a research framework for developing next-generation bioactive restorative materials, highlighting knowledge gaps in long-term stability and standardized protocols.
本叙述性综述系统地研究了天然生物活性物质在牙体组织生物矿化中的新兴作用。通过对2000年至2024年期间通过PubMed、Web of Science和Scopus检索到的同行评审文献进行全面分析，使用包括“天然药物”、“生物矿化”和“牙齿修复”等关键词，我们评估了三个关键方面：（1）当前修复材料（复合树脂、粘合剂）的局限性；（2）天然化合物的作用机制（胶原蛋白保护、矿物质沉积、脱矿抑制）；（3）临床转化面临的挑战。我们的分析表明，植物来源的黄酮类化合物、多酚和生物活性肽在增强再矿化同时解决毒性问题方面显示出特别的前景。综述最后提出了一个开发下一代生物活性修复材料的研究框架，强调了长期稳定性和标准化方案方面的知识空白。
