Mamalo Alireza Soleimani, Alivirdiloo Vahid, Sadeghnejad Azadeh, Hajiabbasi Mobasher, Gargari Morad Kohandel, Valilo Mohammad
Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran.
Medical Doctor Ramsar Campus, Mazandaran University of Medical Sciences, Ramsar, Iran.
Pathol Res Pract. 2023 Nov;251:154845. doi: 10.1016/j.prp.2023.154845. Epub 2023 Oct 5.
Cancer is one of the most common diseases in the world, and various genetic and environmental factors play a key role in its development. Breast cancer is one of the most common and deadly cancers in women. Exosomes are extracellular vesicles (EVs) with an average size of about 100 nm that contain lipids, proteins, microRNAs (miRNAs), and genetic factors and play a significant role in cell signaling, communication, tumorigenesis, and drug resistance. miRNAs are RNAs with about 22 nucleotides, which are synthesized by RNA polymerase and are involved in regulating gene expression, as well as the prevention or progression of cancer. Many studies have indicated the connection between miRNAs and exosomes. According to their findings, it seems that circulating exosomal miRNAs have not been well evaluated as biomarkers for breast cancer diagnosis or monitoring. Therefore, given the importance of miRNAs in exosomes, the goal of the present study was to clarify the relationship between miRNAs in exosomes and the role they play as biomarkers in breast cancer.
癌症是世界上最常见的疾病之一，各种遗传和环境因素在其发展过程中起着关键作用。乳腺癌是女性中最常见且致命的癌症之一。外泌体是平均大小约为100纳米的细胞外囊泡（EVs），其包含脂质、蛋白质、微小RNA（miRNA）和遗传因子，并在细胞信号传导、通讯、肿瘤发生和耐药性方面发挥重要作用。miRNA是约22个核苷酸的RNA，由RNA聚合酶合成，参与调节基因表达以及癌症的预防或进展。许多研究表明了miRNA与外泌体之间的联系。根据他们的研究结果，循环外泌体miRNA作为乳腺癌诊断或监测的生物标志物似乎尚未得到充分评估。因此，鉴于miRNA在外泌体中的重要性，本研究的目的是阐明外泌体中的miRNA之间的关系以及它们作为乳腺癌生物标志物所起的作用。
