Jiang Sufang, Wang Xueji, Cao Tianyu, Kang Rongtian, Huang Lining
Department of Anesthesiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
The Key Laboratory of Neurology, Ministry of Education, Shijiazhuang, Hebei, China.
Front Mol Neurosci. 2023 Sep 28;16:1279985. doi: 10.3389/fnmol.2023.1279985. eCollection 2023.
Clemastine, a Food and Drug Administration (FDA)-approved compound, is recognized as a first-generation, widely available antihistamine that reduces histamine-induced symptoms. Evidence has confirmed that clemastine can transport across the blood-brain barrier and act on specific neurons and neuroglia to exert its protective effect. In this review, we summarize the beneficial effects of clemastine in various central nervous system (CNS) disorders, including neurodegenerative disease, neurodevelopmental deficits, brain injury, and psychiatric disorders. Additionally, we highlight key cellular links between clemastine and different CNS cells, in particular in oligodendrocyte progenitor cells (OPCs), oligodendrocytes (OLs), microglia, and neurons.
氯马斯汀是一种经美国食品药品监督管理局（FDA）批准的化合物，被认为是第一代广泛应用的抗组胺药，可减轻组胺引起的症状。有证据证实，氯马斯汀能够穿过血脑屏障，作用于特定的神经元和神经胶质细胞以发挥其保护作用。在本综述中，我们总结了氯马斯汀在各种中枢神经系统（CNS）疾病中的有益作用，包括神经退行性疾病、神经发育缺陷、脑损伤和精神疾病。此外，我们强调了氯马斯汀与不同CNS细胞之间的关键细胞联系，特别是在少突胶质前体细胞（OPC）、少突胶质细胞（OL）、小胶质细胞和神经元中。
