Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.
NHC Key Laboratory of Myopia (Fudan University); Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China.
BMJ Open. 2022 Feb 21;12(2):e046194. doi: 10.1136/bmjopen-2020-046194.
To investigate anxiety and depression in patients with glaucoma and its correlations with vision-related quality of life (VR-QoL) and visual function indices.
A hospital-based, cross-sectional study.
Shanghai, China PARTICIPANTS: The Hospital Anxiety and Depression Scale and the 25-item National Eye Institute Visual Functioning Questionnaire (NEI VFQ-25) were administered to 446 Chinese patients with glaucoma to assess their psychological disorders, namely anxiety and depression, and VR-QoL, respectively.
Sociodemographic and clinical data were collected at the same time. Multivariate linear regression analysis was carried out to investigate the associations between VR-QoL, visual function indices and psychological disorders. Standardised partial regression analysis was used to identify the variable mostly indicative in evaluating psychological burdens.
The prevalence of anxiety and depression in Chinese patients with glaucoma was 12.11% and 25.78%, respectively. Most of the subscales and the composite score of NEI VFQ-25 were negatively associated with each parameter of anxiety and depression after adjusting for sociodemographic and clinical variables. For visual function indices, only the best-corrected visual acuity of both eyes was correlated with anxiety after adjustment. Standardised partial regression analysis further showed VR-QoL, but not the objective visual function indices, was mostly relevant to psychological disturbances.
Anxiety and depression were common in Chinese patients with glaucoma. Self-reported VR-QoL was beneficial in assessing psychological status of patients with glaucoma, while objective visual function indices provide little hint on it.
调查青光眼患者的焦虑和抑郁状况及其与视功能相关生存质量（VR-QoL）和视功能指标的相关性。
基于医院的横断面研究。
中国上海。
本研究纳入 446 例中国青光眼患者，采用医院焦虑抑郁量表和 25 项全国眼科研究所视功能问卷（NEI VFQ-25）分别评估其心理障碍（焦虑和抑郁）和 VR-QoL。
同时收集患者的人口统计学和临床资料。采用多元线性回归分析探讨 VR-QoL、视功能指标与心理障碍之间的相关性。采用标准化偏回归分析确定评估心理负担的主要变量。
中国青光眼患者的焦虑和抑郁发生率分别为 12.11%和 25.78%。在调整人口统计学和临床变量后，NEI VFQ-25 的大部分子量表和综合评分与焦虑和抑郁的各参数呈负相关。对于视功能指标，仅双眼最佳矫正视力与焦虑相关。标准化偏回归分析进一步显示 VR-QoL 与心理障碍密切相关，而客观视功能指标则相关性不大。
中国青光眼患者中焦虑和抑郁较为常见。自我报告的 VR-QoL 有助于评估青光眼患者的心理状态，而客观视功能指标对此提示作用有限。
