Edward A. Doisy Department of Biochemistry & Molecular Biology, Saint Louis University School of Medicine, St. Louis, Missouri.
Mo Med. 2023 Sep-Oct;120(5):359-366.
Antiphospholipid syndrome (APS) is an autoimmune condition affecting young patients, primarily women, negatively impacting their quality of life. APS is under-recognized and underdiagnosed and can have devastating results if untreated, mainly due to uncontrolled thrombosis. Research in the past decades has led to several breakthroughs with important implications for clinical practice. Here, we summarize the state of APS diagnosis, treatment, pathophysiology, and research directions that hold promise for advancing diagnosis and treatment.
抗磷脂综合征(APS)是一种影响年轻患者(主要为女性)的自身免疫性疾病,会降低其生活质量。如果不加治疗,APS 可能会导致破坏性的后果,主要是由于血栓形成失控。过去几十年的研究取得了一些突破性进展,对临床实践具有重要意义。在这里,我们总结了 APS 的诊断、治疗、病理生理学以及有希望推进诊断和治疗的研究方向。