一种由 circVPS13D 编码的新型蛋白通过靶向鱼类中的 MAVS 来减弱抗病毒先天免疫。
A novel protein encoded by circVPS13D attenuates antiviral innate immunity by targeting MAVS in teleost fish.
机构信息
Laboratory of Fish Molecular Immunology, College of Fisheries and Life Science, Shanghai Ocean University , Shanghai, China.
Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology , Qingdao, China.
出版信息
J Virol. 2023 Nov 30;97(11):e0088623. doi: 10.1128/jvi.00886-23. Epub 2023 Oct 16.
The expression of circVPS13D was upregulated with SCRV invasion, which proved that circVPS13D was involved in the regulation of the antiviral immune response. Our study revealed that the existence of circVPS13D promoted the replication of SCRV. Functionally, circVPS13D negatively regulates the antiviral responses of fish. Mechanistically, we confirmed that circVPS13D inhibited RLRs antiviral signaling pathway via the encoded protein VPS13D-170aa by targeting MAVS. Our study provided novel insights into the roles of protein-coding circRNAs and supported VPS13D-170aa as a negative regulator in the antiviral immune responses of teleost fish.
circVPS13D 的表达随着 SCRV 的入侵而上调，这证明 circVPS13D 参与了抗病毒免疫反应的调节。我们的研究表明 circVPS13D 的存在促进了 SCRV 的复制。从功能上讲，circVPS13D 负调控鱼类的抗病毒反应。从机制上讲，我们通过靶向 MAVS 证实 circVPS13D 通过编码蛋白 VPS13D-170aa 抑制 RLRs 抗病毒信号通路。我们的研究为蛋白编码 circRNAs 的作用提供了新的见解，并支持 VPS13D-170aa 作为硬骨鱼类抗病毒免疫反应的负调节剂。
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