Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, 100069, PR China.
Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, PR China.
ACS Sens. 2023 Oct 27;8(10):3659-3679. doi: 10.1021/acssensors.3c01538. Epub 2023 Oct 16.
For diabetics, taking regular blood glucose measurements is crucial. However, traditional blood glucose monitoring methods are invasive and unfriendly to diabetics. Recent studies have proposed a biofluid-based glucose sensing technique that creatively combines wearable devices with noninvasive glucose monitoring technology to enhance diabetes management. This is a revolutionary advance in the diagnosis and management of diabetes, reflects the thoughtful modernization of medicine, and promotes the development of digital medicine. This paper reviews the research progress of noninvasive continuous blood glucose monitoring (CGM), with a focus on the biological liquids that replace blood in monitoring systems, the technical principles of continuous noninvasive glucose detection, and the output and calibration of sensor signals. In addition, the existing limits of noninvasive CGM systems and prospects for the future are discussed. This work serves as a resource for further promoting the development of noninvasive CGM systems.
对于糖尿病患者来说，定期进行血糖测量至关重要。然而，传统的血糖监测方法具有侵入性，对糖尿病患者不够友好。最近的研究提出了一种基于生物流体的葡萄糖传感技术，该技术创造性地将可穿戴设备与非侵入性血糖监测技术相结合，以加强糖尿病管理。这是糖尿病诊断和管理方面的一项革命性进展，体现了医学的周到现代化，并推动了数字医学的发展。本文综述了非侵入性连续血糖监测（CGM）的研究进展，重点介绍了在监测系统中替代血液的生物液体、连续非侵入性葡萄糖检测的技术原理，以及传感器信号的输出和校准。此外，还讨论了非侵入性 CGM 系统目前存在的局限性和未来的发展前景。这项工作为进一步推动非侵入性 CGM 系统的发展提供了资源。
