Department of Microbiology, Faculty of Life Sciences, Ahmadu Bello University, Zaria, Nigeria.
Department of Microbiology, School of Life Sciences, Federal University of Technology, Minna, Nigeria; African Center of Excellence for Mycotoxin and Food Safety, Federal University of Technology Minna, Nigeria.
Res Microbiol. 2024 Mar-Apr;175(3):104111. doi: 10.1016/j.resmic.2023.104111. Epub 2023 Oct 14.
Biofilms have been recognized as a serious threat to public health as it protects microbes from antimicrobials, immune defence mechanisms, chemical treatments and nutritional stress. Biofilms are also a source of concern in industries and water treatment because their presence compromises the integrity of equipment. To overcome these problems, it is necessary to identify novel anti-biofilm compounds. Products of microorganisms have been identified as promising broad-spectrum anti-biofilm agents. These natural products include biosurfactants, antimicrobial peptides, enzymes and bioactive compounds. Anti-biofilm products of microbial origin are chemically diverse and possess a broad spectrum of activities against biofilms. The objective of this review is to give an overview of the different types of microbial anti-biofilm products and their mechanisms of action.
生物膜已被公认为对公共健康的严重威胁，因为它可以保护微生物免受抗菌药物、免疫防御机制、化学处理和营养压力的影响。生物膜也是工业和水处理领域关注的一个问题，因为它们的存在会破坏设备的完整性。为了解决这些问题，有必要确定新型抗生物膜化合物。微生物的产物已被确定为有前途的广谱抗生物膜剂。这些天然产物包括生物表面活性剂、抗菌肽、酶和生物活性化合物。微生物来源的抗生物膜产品在化学上具有多样性，并对生物膜具有广泛的活性。本综述的目的是概述不同类型的微生物抗生物膜产品及其作用机制。
