Tropical Infectious Diseases Research and Education Centre, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
School of Science, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, Selangor, Malaysia.
Int Microbiol. 2019 Dec;22(4):403-409. doi: 10.1007/s10123-019-00066-4. Epub 2019 Mar 7.
A biofilm is a community of microorganisms attached to a surface and embedded in a matrix of extracellular polymeric substances. Biofilms confer resistance towards conventional antibiotic treatments; thus, there is an urgent need for newer and more effective antimicrobial agents that can act against these biofilms. Due to this situation, various studies have been done to investigate the anti-biofilm effects of natural products including bioactive compounds extracted from microorganisms such as Actinobacteria. This review provides an insight into the anti-biofilm potential of Actinobacteria against various pathogenic bacteria, which hopefully provides useful information, guidance, and improvements for future antimicrobial studies. Nevertheless, further research on the anti-biofilm mechanisms and compound modifications to produce more potent anti-biofilm effects are required.
生物膜是附着在表面并嵌入细胞外聚合物基质中的微生物群落。生物膜对传统抗生素治疗具有抗性；因此，迫切需要新的、更有效的抗菌剂来对抗这些生物膜。鉴于这种情况，已经进行了各种研究来调查天然产物的抗生物膜作用，包括从微生物（如放线菌）中提取的生物活性化合物。 本综述深入探讨了放线菌对各种致病菌的抗生物膜潜力，希望为未来的抗菌研究提供有用的信息、指导和改进。 然而，仍需要进一步研究抗生物膜机制和化合物修饰以产生更有效的抗生物膜作用。
