Li Dan, Zhong Zhangfeng, Ko Chung-Nga, Tian Tiantian, Yang Chao
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Macao Centre for Research and Development in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China.
Br J Pharmacol. 2025 May;182(10):2159-2180. doi: 10.1111/bph.16267. Epub 2023 Nov 27.
Sinomenine is an active substance extracted from the traditional Chinese medicine Sinomenium acutum. Sinomenine has been shown to mediate a wide range of pharmacological actions and is known to possess good anti-inflammatory, immunosuppressive, antitumor, neuroprotective, antiarrhythmic and other pharmacological effects. Understanding the underlying mechanisms and the association between the targets and the pharmaceutical effects on different diseases is crucial to the discovery and design of new treatment strategies. In this review, we aim to give a systematic and comprehensive overview of the research progress of sinomenine over the past 20 years. We first describe the metabolism of sinomenine in vivo and then summarize the pharmacological actions of sinomenine on different diseases. Furthermore, the potential binding properties of sinomenine and the potential of developing new sinomenine-based drugs are also reviewed. LINKED ARTICLES: This article is part of a themed issue Natural Products and Cancer: From Drug Discovery to Prevention and Therapy. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v182.10/issuetoc.
青藤碱是从传统中药青风藤中提取的一种活性物质。已证明青藤碱可介导多种药理作用，并且已知具有良好的抗炎、免疫抑制、抗肿瘤、神经保护、抗心律失常等药理作用。了解其潜在机制以及靶点与不同疾病药物效应之间的关联对于发现和设计新的治疗策略至关重要。在本综述中，我们旨在对青藤碱在过去20年的研究进展进行系统而全面的概述。我们首先描述青藤碱在体内的代谢，然后总结青藤碱对不同疾病的药理作用。此外，还综述了青藤碱的潜在结合特性以及开发基于青藤碱的新药的潜力。相关文章：本文是主题为“天然产物与癌症：从药物发现到预防与治疗”的一期特刊的一部分。要查看本节中的其他文章，请访问http://onlinelibrary.wiley.com/doi/10.1111/bph.v182.10/issuetoc。
