Stingl Julia V, Greslechner R, Brandl Caroline, Heid Iris M, Hoffmann Esther M, Pfeiffer Norbert, Schuster Alexander K
Augenklinik und Poliklinik, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Langenbeckstr. 1, 55131, Mainz, Deutschland.
Klinik und Poliklinik für Augenheilkunde, Universitätsklinikum Regensburg, Regensburg, Deutschland.
Ophthalmologie. 2023 Nov;120(11):1088-1097. doi: 10.1007/s00347-023-01943-0. Epub 2023 Oct 17.
Glaucoma is not a rare entity but because very few symptoms occur and visual field defects are frequently first recognized at a late stage, a large proportion of glaucoma diseases remain undetected. The aim of this study was to identify the proportion of undiagnosed glaucoma in German population-based cohort studies and to contextualize them in the context of the literature.
The prevalence of glaucoma in the Gutenberg Health Study (GHS) and the age-related investigations on health of the University of Regensburg (AugUR) was evaluated based on visual field examinations and optic disc color photography according to the ISGEO criteria. Furthermore, the self-reported glaucoma diagnoses were collected and the proportion of undiagnosed glaucoma was determined.
The proportion of undiagnosed glaucoma was 55% in the GHS, and 53% in the AugUR study. The results correlate with results from previous studies from other countries in which the proportion of unrecognized glaucoma ranged from 33% to 78%. In the GHS and the AugUR study the proportion of undiagnosed glaucoma was higher in younger age groups and in women.
Roughly every second case of glaucoma is undetected. As the symptoms are often nonspecific or take a long time to appear, there is a risk of advanced glaucomatous visual field defects or blindness due to a lack of glaucoma awareness. Studies have shown that a systematic screening can halve this risk.
青光眼并非罕见疾病,但由于症状极少出现,且视野缺损往往在晚期才被首次发现,很大一部分青光眼病例仍未被检测出来。本研究的目的是确定德国基于人群的队列研究中未确诊青光眼的比例,并将其与文献中的情况相结合。
根据ISGEO标准,通过视野检查和视盘彩色摄影评估古登堡健康研究(GHS)和雷根斯堡大学健康老龄化调查(AugUR)中青光眼的患病率。此外,收集自我报告的青光眼诊断情况,并确定未确诊青光眼的比例。
GHS中未确诊青光眼的比例为55%,AugUR研究中为53%。这些结果与其他国家先前研究的结果相关,在这些研究中,未被识别的青光眼比例在33%至78%之间。在GHS和AugUR研究中,未确诊青光眼的比例在较年轻年龄组和女性中更高。
大约每两例青光眼中就有一例未被检测出来。由于症状往往不具有特异性或需要很长时间才会出现,因缺乏青光眼意识而存在青光眼晚期视野缺损或失明的风险。研究表明,系统筛查可将这种风险减半。