Ganzhou Jingkai District People's Hospital, Ganzhou, China.
Department of Traumatology, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Mol Med. 2023 Oct 17;29(1):136. doi: 10.1186/s10020-023-00731-5.
Hepatocellular carcinoma (HCC) is the most common primary liver cancer. It is characterized by occult onset resulting in most patients being diagnosed at advanced stages and with poor prognosis. Exosomes are nanoscale vesicles with a lipid bilayer envelope released by various cells under physiological and pathological conditions, which play an important role in the biological information transfer between cells. There is growing evidence that HCC cell-derived exosomes may contribute to the establishment of a favorable microenvironment that supports cancer cell proliferation, invasion, and metastasis. These exosomes not only provide a versatile platform for diagnosis but also serve as a vehicle for drug delivery. In this paper, we review the role of exosomes involved in the proliferation, migration, and metastasis of HCC and describe their application in HCC diagnosis and treatment. We also discuss the prospects of exosome application in HCC and the research challenges.
肝细胞癌（HCC）是最常见的原发性肝癌。其特点为隐匿性发病，导致大多数患者在晚期诊断，预后不良。外泌体是在生理和病理条件下由各种细胞释放的具有双层脂膜囊泡，在细胞间的生物信息传递中发挥重要作用。越来越多的证据表明，HCC 细胞来源的外泌体可能有助于建立有利于癌细胞增殖、侵袭和转移的有利微环境。这些外泌体不仅为诊断提供了一个多功能平台，而且还作为药物传递的载体。本文综述了外泌体在 HCC 增殖、迁移和转移中的作用，并描述了它们在 HCC 诊断和治疗中的应用。我们还讨论了外泌体在 HCC 中的应用前景和研究挑战。
