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锌指CCHC型超家族蛋白在甲状腺癌中的差异表达及其与肿瘤免疫的关系。

Differential expression of zinc finger CCHC-type superfamily proteins in thyroid carcinoma and their associations with tumor immunity.

作者信息

Yin Yin, Chen Jing, Chen Qian, He Hongyan, Zhu Nannan, Xia Pengcheng, Yu Chunli, Meng Lingyun

机构信息

Department of Clinical Laboratory Medicine, The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong, China.

Discipline of Anatomy and Pathology, Shandong First Medical University, Jinan, Shandong, China.

出版信息

Thyroid Res. 2023 Oct 17;16(1):42. doi: 10.1186/s13044-023-00185-1.

DOI:10.1186/s13044-023-00185-1
PMID:37848968
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10580525/
Abstract

BACKGROUND

The zinc-finger CCHC-type (ZCCHC) superfamily proteins are characterized by the shared sequence CX2-CX4-HX4-C and thought to own high affinity to single-stranded nucleic acids, particularly RNAs. In humans, a total of 24 ZCCHC proteins have been annotated in the HUGO Gene Nomenclature Committee (HGNC, https://www.genenames.org/ ) database with most of these members involved in multiple steps of RNA metabolism. Many studies have indicated that the ZCCHC genes play a regulatory role in the development and progression of solid tumors. To date, the expression pattern and prognostic value of ZCCHC factors in thyroid carcinomas have not been reported.

METHODS

Bioinformatics analyses on the functions of ZCCHC factors in thyroid carcinoma (THCA) patients were performed based on various databases, i.e., TCGA, GEPIA, Kaplan-Meier Plotter, and TIMER.

RESULTS

Compared with normal tissues, the expression of ZCCHC12 mRNA was significantly increased in THCA tissues. And it was associated with the overall survival of THCA patients, based on the Kaplan-Meier Plotter database. Furthermore, the expression levels of all ZCCHCs were correlated with tumor stages, implying its high relevance to THCA, specifically its immunity.

CONCLUSION

The ZCCHC genes, represented by ZCCHC12, are differentially expressed in THCA staging. These genes are associated with immune infiltration of THCA and identified as the potential therapeutic targets for immunotherapy in THCA patients, which are possible novel biomarkers for the treatment of THCA.

摘要

背景

锌指CCHC型（ZCCHC）超家族蛋白的特征是具有共同序列CX2-CX4-HX4-C，并且被认为对单链核酸，尤其是RNA具有高亲和力。在人类中，人类基因组命名委员会（HGNC，https://www.genenames.org/ ）数据库中共注释了24种ZCCHC蛋白，其中大多数成员参与RNA代谢的多个步骤。许多研究表明，ZCCHC基因在实体瘤的发生和发展中起调节作用。迄今为止，尚未报道ZCCHC因子在甲状腺癌中的表达模式和预后价值。

方法

基于各种数据库，即TCGA、GEPIA、Kaplan-Meier Plotter和TIMER，对甲状腺癌（THCA）患者中ZCCHC因子的功能进行生物信息学分析。

结果

与正常组织相比，THCA组织中ZCCHC12 mRNA的表达显著增加。根据Kaplan-Meier Plotter数据库，它与THCA患者的总生存期相关。此外，所有ZCCHC的表达水平均与肿瘤分期相关，这意味着它与THCA高度相关，特别是其免疫方面。

结论

以ZCCHC12为代表的ZCCHC基因在THCA分期中存在差异表达。这些基因与THCA的免疫浸润相关，并被确定为THCA患者免疫治疗的潜在治疗靶点，可能是治疗THCA的新型生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a9/10580525/b3a8ac14ab11/13044_2023_185_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a9/10580525/45c71a137337/13044_2023_185_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a9/10580525/fd85a3f4e48f/13044_2023_185_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a9/10580525/9dc4c2db2855/13044_2023_185_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a9/10580525/3bfc579a5fb9/13044_2023_185_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a9/10580525/8add12afd7e8/13044_2023_185_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a9/10580525/ccacc456be61/13044_2023_185_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a9/10580525/e5fccfa3bb3e/13044_2023_185_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a9/10580525/98b4f6773d06/13044_2023_185_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a9/10580525/b3a8ac14ab11/13044_2023_185_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a9/10580525/45c71a137337/13044_2023_185_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a9/10580525/fd85a3f4e48f/13044_2023_185_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a9/10580525/9dc4c2db2855/13044_2023_185_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a9/10580525/3bfc579a5fb9/13044_2023_185_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a9/10580525/8add12afd7e8/13044_2023_185_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a9/10580525/ccacc456be61/13044_2023_185_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a9/10580525/e5fccfa3bb3e/13044_2023_185_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a9/10580525/98b4f6773d06/13044_2023_185_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a9/10580525/b3a8ac14ab11/13044_2023_185_Fig7_HTML.jpg

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本文引用的文献

1
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Front Immunol. 2022 Sep 9;13:975787. doi: 10.3389/fimmu.2022.975787. eCollection 2022.
2
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Aging (Albany NY). 2022 Sep 19;14(18):7505-7516. doi: 10.18632/aging.204296.
3
RNA-binding protein ZCCHC4 promotes human cancer chemoresistance by disrupting DNA-damage-induced apoptosis.
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Signal Transduct Target Ther. 2022 Jul 20;7(1):240. doi: 10.1038/s41392-022-01033-8.
4
ZCCHC17 Served as a Predictive Biomarker for Prognosis and Immunotherapy in Hepatocellular Carcinoma.ZCCHC17作为肝细胞癌预后和免疫治疗的预测生物标志物。
Front Oncol. 2022 Jan 6;11:799566. doi: 10.3389/fonc.2021.799566. eCollection 2021.
5
Identification of novel targets of miR-622 in hepatocellular carcinoma reveals common regulation of cooperating genes and outlines the oncogenic role of zinc finger CCHC-type containing 11.鉴定 miR-622 在肝癌中的新型靶标揭示了合作基因的共同调控，并概述了含锌指 CCHC 型 11 的致癌作用。
Neoplasia. 2021 May;23(5):502-514. doi: 10.1016/j.neo.2021.04.001. Epub 2021 Apr 24.
6
The importance of the RET gene in thyroid cancer and therapeutic implications.RET 基因在甲状腺癌中的重要性及其治疗意义。
Nat Rev Endocrinol. 2021 May;17(5):296-306. doi: 10.1038/s41574-021-00470-9. Epub 2021 Feb 18.
7
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J Cell Mol Med. 2021 Feb;25(3):1406-1414. doi: 10.1111/jcmm.16223. Epub 2020 Dec 20.
8
Artificial intelligence to predict the BRAFV600E mutation in patients with thyroid cancer.人工智能预测甲状腺癌患者的 BRAFV600E 突变。
PLoS One. 2020 Nov 25;15(11):e0242806. doi: 10.1371/journal.pone.0242806. eCollection 2020.
9
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Nucleic Acids Res. 2021 Jan 8;49(D1):D939-D946. doi: 10.1093/nar/gkaa980.
10
Anlotinib as a molecular targeted therapy for tumors.安罗替尼作为一种肿瘤分子靶向治疗药物。
Oncol Lett. 2020 Aug;20(2):1001-1014. doi: 10.3892/ol.2020.11685. Epub 2020 May 28.