Department of Biochemistry and Molecular Cell Biology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China.
RNA Biol. 2021 Dec;18(12):2107-2126. doi: 10.1080/15476286.2021.1909320. Epub 2021 May 4.
The zinc finger CCHC-type (ZCCHC) superfamily proteins, characterized with the consensus sequence C-X-C-X-H-X-C, are accepted to have high-affinity binding to single-stranded nucleic acids, especially single-stranded RNAs. In human beings 25 ZCCHC proteins have been annotated in the HGNC database. Of interest is that among the family, most members are involved in the multiple steps of RNA metabolism. In this review, we focus on the diverged roles of human ZCCHC proteins on RNA transcription, biogenesis, splicing, as well as translation and degradation.
锌指 CCHC 型（ZCCHC）超家族蛋白的特征序列为 C-X-C-X-H-X-C，被认为具有与单链核酸，尤其是单链 RNA 高亲和力的结合能力。在人类基因组中，HGNC 数据库注释了 25 种 ZCCHC 蛋白。有趣的是，在该家族中，大多数成员都参与了 RNA 代谢的多个步骤。在这篇综述中，我们重点介绍了人类 ZCCHC 蛋白在 RNA 转录、生物发生、剪接以及翻译和降解中的不同作用。
