Department of Medical Devices, National Institute of Pharmaceutical Education and Research- Ahmedabad, Opposite Air Force Station, Gandhinagar, Gujarat, India.
Department of Medical Devices, National Institute of Pharmaceutical Education and Research- Kolkata, Chunilal Bhawan, Kolkata, India.
Front Immunol. 2023 Sep 27;14:1245343. doi: 10.3389/fimmu.2023.1245343. eCollection 2023.
Being a complex physiological process involving the removal of damaged tissue debris and creating a new microenvironment for host tissue regeneration, wound healing is still a major challenge for healthcare professionals. Disruption of this process can lead to tissue inflammation, pathogenic infections, and scar formation. Current wound healing treatments primarily focus on passive tissue healing, lacking active engagement in the healing process. In recent years, a new class of functional biomaterials based on piezoelectric properties has emerged, which can actively participate in the wound healing process by harnessing mechanical forces generated from body movement. Herein, we have fabricated a bioactive Cellulose Acetate (CA) electrospun nanofibrous mat incorporating zinc oxide (ZnO) and investigated its efficiency for accelerated wound healing. We have characterized the physicochemical properties of the fabricated nanofibrous mats using various assays, including SEM, FTIR, TGA, mechanical testing, degradation analysis, porosity measurement, hemolysis assay, and piezoelectric d coefficient measurement. Through our investigation, we discovered the tunned piezoelectric coefficient of fabricated specimens due to incorporating ZnO into the CA fibers. studies also confirmed enhanced cell adhesion, proliferation, and migration, indicating faster wound healing potential. Overall, our findings support the efficacy of piezoelectric-based ZnO-incorporated bioactive CA nanofibrous mats for efficient wound healing.
作为一个涉及清除受损组织碎片并为宿主组织再生创造新的微环境的复杂生理过程，伤口愈合仍然是医疗保健专业人员的主要挑战。该过程的中断会导致组织炎症、病原感染和疤痕形成。目前的伤口愈合治疗主要侧重于被动组织愈合，缺乏对愈合过程的主动参与。近年来，出现了一类基于压电特性的新型功能生物材料，它们可以通过利用身体运动产生的机械力，积极参与伤口愈合过程。在这里，我们制备了一种含有氧化锌（ZnO）的活性醋酸纤维素（CA）静电纺纳米纤维垫，并研究了其加速伤口愈合的效率。我们使用各种分析方法，包括 SEM、FTIR、TGA、机械测试、降解分析、孔隙率测量、溶血试验和压电 d 系数测量，对制备的纳米纤维垫的物理化学性质进行了表征。通过研究，我们发现由于将 ZnO 掺入 CA 纤维中，制备的样品的可调谐压电系数。研究还证实了增强的细胞粘附、增殖和迁移，表明具有更快的伤口愈合潜力。总的来说，我们的研究结果支持基于压电的 ZnO 掺入活性 CA 纳米纤维垫在高效伤口愈合方面的功效。
