宿主细胞器与病原体的接触部位：是福还是祸？
Contact sites between host organelles and pathogens: boon or bane?
机构信息
Max Planck Institute for Biology of Ageing, Cologne, Germany.
Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
出版信息
mSphere. 2023 Dec 20;8(6):e0044823. doi: 10.1128/msphere.00448-23. Epub 2023 Oct 18.
Abstract
A microbe and its host are in constant communication. An emerging platform for direct communication is the membrane contact sites that form between several pathogens and host organelles. Here, we review our progress on the molecular mechanisms underlying contact sites between host mitochondria and the human parasite . We discuss open questions regarding their function during infection as well as those formed between the host endoplasmic reticulum and .
摘要
微生物与其宿主不断进行交流。一种新兴的直接交流平台是在几种病原体和宿主细胞器之间形成的膜接触位点。在这里，我们回顾了我们在宿主线粒体与人类寄生虫之间接触位点的分子机制方面的进展。我们讨论了在感染过程中以及在宿主内质网和之间形成的这些接触位点的功能方面的悬而未决的问题。
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