Department of Ophthalmology, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea.
Department of Ophthalmology, Konyang University College of Medicine, Daejeon, Republic of Korea.
PLoS One. 2023 Oct 18;18(10):e0292942. doi: 10.1371/journal.pone.0292942. eCollection 2023.
To identify how the inner retinal layer and microvasculature change with age by analyzing the relationships of ganglion cell-inner plexiform layer (GC-IPL) thickness, vessel density (VD), and the ratio of these measurements with age in healthy eyes.
Participants were divided into five groups according to age. The GC-IPL thickness, VD, and GC-IPL/VD ratio were compared among the groups. Linear regression analyses were performed to identify relationships of GC-IPL/VD ratio with age.
The average GC-IPL thicknesses were 84.84 ± 5.28, 84.22 ± 5.30, 85.20 ± 6.29, 83.29 ± 7.06, and 82.26 ± 5.62 μm in the 20s, 30s, 40s, 50s, and 60s age groups, respectively. The VDs were 20.94 ± 1.50, 21.06 ± 1.50, 20.99 ± 1.03, 20.71 ± 0.93, and 19.74 ± 1.73 mm-1 in the 20s, 30s, 40s, 50s, and 60s age groups, respectively. The GC-IPL/VD ratio was 4.05, 4.00, 4.06, 4.02, and 4.17 in each group, respectively, and the ratio of the 60s age group was significantly higher than that of other groups. In linear regression analyses, the GC-IPL/VD ratio was significantly associated with age in the participants aged ≥ 50 years (B = 0.014, P = 0.013), whereas it was not in the participants aged < 50 years (B = 0.003, P = 0.434).
GC-IPL thickness and macular VD showed a tendency to decrease beginning in the 50s age group and the GC-IPL/VD ratio was significantly increased in the 60s age group. Additionally, the GC-IPL/VD ratio was positively associated with age in subjects aged ≥ 50 years, which implies a more pronounced decline over time in VD rather than GC-IPL thickness.
通过分析健康眼中神经节细胞-内丛状层（GC-IPL）厚度、血管密度（VD）和这些测量值与年龄的比值之间的关系，来确定内视网膜层和微血管随年龄的变化情况。
参与者根据年龄分为五组。比较各组间 GC-IPL 厚度、VD 和 GC-IPL/VD 比值。进行线性回归分析以确定 GC-IPL/VD 比值与年龄的关系。
20 岁、30 岁、40 岁、50 岁和 60 岁年龄组的平均 GC-IPL 厚度分别为 84.84±5.28、84.22±5.30、85.20±6.29、83.29±7.06 和 82.26±5.62μm。20 岁、30 岁、40 岁、50 岁和 60 岁年龄组的 VD 分别为 20.94±1.50、21.06±1.50、20.99±1.03、20.71±0.93 和 19.74±1.73mm-1。各组的 GC-IPL/VD 比值分别为 4.05、4.00、4.06、4.02 和 4.17，60 岁年龄组的比值明显高于其他组。在线性回归分析中，年龄≥50 岁的参与者中 GC-IPL/VD 比值与年龄显著相关（B=0.014，P=0.013），而年龄<50 岁的参与者中则不相关（B=0.003，P=0.434）。
自 50 岁年龄组开始，GC-IPL 厚度和黄斑 VD 呈下降趋势，60 岁年龄组的 GC-IPL/VD 比值明显升高。此外，年龄≥50 岁的受试者中 GC-IPL/VD 比值与年龄呈正相关，这意味着 VD 的下降速度比 GC-IPL 厚度更明显。
