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甲基（甲氧基甲基）亚硝胺诱导的F344大鼠原发性肾间充质肿瘤中激活的K-ras和N-ras癌基因

Activated K-ras and N-ras oncogenes in primary renal mesenchymal tumors induced in F344 rats by methyl(methoxymethyl)nitrosamine.

作者信息

Sukumar S, Perantoni A, Reed C, Rice J M, Wenk M L

出版信息

Mol Cell Biol. 1986 Jul;6(7):2716-20. doi: 10.1128/mcb.6.7.2716-2720.1986.

DOI:10.1128/mcb.6.7.2716-2720.1986
PMID:3785207
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC367829/
Abstract

Administration of methyl(methoxymethyl)nitrosamine to newborn Fischer 344 rats results in the preferential induction of renal tumors arising from the mesenchymal component of the kidney. DNA from a significant proportion of these tumors was capable of transforming NIH/3T3 cells. This report describes the renal tumor model, the detection of two different ras transforming genes in the kidney tumors (the N-ras oncogene in 1 and K-ras oncogene in 10 kidney tumors) and the characterization of DNA sequences specifying the transformed phenotype.

摘要

给新生的Fischer 344大鼠施用甲基（甲氧基甲基）亚硝胺会优先诱导源自肾脏间充质成分的肾肿瘤。这些肿瘤中相当一部分的DNA能够转化NIH/3T3细胞。本报告描述了肾肿瘤模型、在肾肿瘤中检测到的两种不同的ras转化基因（1个肾肿瘤中的N-ras癌基因和10个肾肿瘤中的K-ras癌基因）以及确定转化表型的DNA序列的特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/923e/367829/e0087ca998f7/molcellb00091-0441-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/923e/367829/762adc6ee86b/molcellb00091-0439-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/923e/367829/18218a6e69b7/molcellb00091-0440-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/923e/367829/e0087ca998f7/molcellb00091-0441-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/923e/367829/762adc6ee86b/molcellb00091-0439-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/923e/367829/18218a6e69b7/molcellb00091-0440-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/923e/367829/e0087ca998f7/molcellb00091-0441-a.jpg

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H-ras activation in benign and self-regressing skin tumors (keratoacanthomas) in both humans and an animal model system.

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