Towers G N, Arnason T, Wat C K, Graham E A, Lam J, Mitchell J L
Contact Dermatitis. 1979 May;5(3):140-4. doi: 10.1111/j.1600-0536.1979.tb04825.x.
Polyacetylenes and their thiophene derivatives were tested for their effects on human skin. Topically applied alpha-terthienyl evoked bi-phasic phototoxic dermatitis and the appearance of 'sunburn' cells in human epidermis. None of 11 polyacetylenes had the same effect although they mimicked alpha-terthienyl in their phototoxic effects on Candida albicans and certain pathogenic microorganisms. The UV-mediated antibiotic activity of the compounds and their apparent lack of phototoxicity towards the skin suggest a potential topical therapeutic role for them in yeast, fungal and bacterial infections and light-responsive dermatoses. Their topical sensitizing capacity, however, has not yet been studied.
对聚乙炔及其噻吩衍生物进行了人体皮肤效应测试。局部应用α-三联噻吩可诱发双相光毒性皮炎，并在人体表皮中出现“晒伤”细胞。11种聚乙炔均无相同效果，尽管它们对白色念珠菌和某些致病微生物的光毒性作用与α-三联噻吩相似。这些化合物的紫外线介导的抗生素活性以及它们对皮肤明显缺乏光毒性表明它们在酵母、真菌和细菌感染以及光反应性皮肤病中具有潜在的局部治疗作用。然而，它们的局部致敏能力尚未得到研究。
