Towers G H, Wat C K, Graham E A, Bandoni R J, Chan G Q, Mitchell J C, Lam J
Lloydia. 1977 Sep-Oct;40(5):487-98.
A survey of North, Central, and South American composites, and of certain polyacetylenic compounds occurring in them, confirmed that the ultraviolet-mediated antibiotic activity against Candida albicans can be ascribed to the presence of particular polyacetylenes and their thiophene derivatives. Leaves, stems, roots, and achenes were assayed separately. An attempt was made to relate the phototoxic activity of specific compounds to their chemical structures. Most composites tested were not phototoxic against Candida, but many were antibiotic. The antibiotic activity also appears to be caused by polyacetylenes. Of 65 sequiterpene lactones assayed, only a few were found to be antibiotic, and only one, glaucolide G, was phototoxic.
对北美洲、中美洲和南美洲的菊科植物以及其中存在的某些聚乙炔化合物进行的一项调查证实，紫外线介导的针对白色念珠菌的抗生素活性可归因于特定聚乙炔及其噻吩衍生物的存在。分别对叶子、茎、根和瘦果进行了检测。试图将特定化合物的光毒性活性与其化学结构联系起来。大多数测试的菊科植物对白色念珠菌没有光毒性，但许多具有抗生素活性。抗生素活性似乎也由聚乙炔引起。在检测的65种倍半萜内酯中，仅发现少数具有抗生素活性，只有一种，即绿胶内酯G，具有光毒性。
