70 岁以上健康活跃的居家人群的叶酸、维生素 B12 和维生素 D 状况。

Folate, vitamin B12 and vitamin D status in healthy and active home-dwelling people over 70 years.

机构信息

Institute of Food Science and Human Nutrition, Leibniz University Hannover, Hannover, Germany.

出版信息

BMC Geriatr. 2023 Oct 18;23(1):673. doi: 10.1186/s12877-023-04391-2.

DOI:10.1186/s12877-023-04391-2

PMID:37853337

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10585793/

Abstract

BACKGROUND

Ageing is characterised by physiological changes that can affect the nutrient availability and requirements. In particular, the status of vitamin D, cobalamin and folate has often been found to be critical in older people living in residential care. However, there is a lack of studies investigating the status of these nutrients in healthy and active home-dwelling elderly people.

METHODS

The aim of this cross-sectional study was to assess the status of vitamin D based on serum concentrations of 25-hydroxycholecalciferol [25-(OH)D], cobalamin based on serum concentrations of holotranscobalamin (holoTC) and folate based on red blood cell (RBC) folate in unsupplemented, healthy and active German home-dwelling subjects ≥ 70 years of age (n = 134, mean ± SD: 75.8 ± 4.5 years). Dietary intake was assessed by 3-day food recalls. The study was conducted between March and November of 2021 (during the COVID-19 pandemic).

RESULTS

The mean 25-(OH)D concentration was high at 85.1 ± 26.0 nmol/L, while the majority of women (92%) and men (94%) had 25-(OH)D concentrations ≥ 50 nmol/L. Less than 10% of men and women had 25-(OH)D concentrations < 50 nmol/L. The mean holoTC concentration was 88.9 ± 33.7 pmol/L (94.8 ± 34.6 pmol/L in women and 73.6 ± 25.6 in men). Only 8% of the women were cobalamin deficient (< 50 pmol/L holoTC) compared to 22% of the men. The mean RBC folate concentration was 831 ± 244 nmol/L, while the prevalence of folate deficiency was 10%. Linear regression analysis showed that only folate equivalent intake was associated with the relevant nutrient status marker.

CONCLUSION

Our findings suggest that healthy, independently living older people with high levels of education, physical activity, and health awareness are not necessarily at higher risk of vitamin D, folate and cobalamin deficiency. Further studies are needed to verify these findings and to identify lifestyle and dietary patterns that can predict adequate nutrient status for healthy ageing.

TRIAL REGISTRATION

This study is officially recorded in the German Clinical Trials Register (DRKS00021302).

摘要

背景

衰老的特征是生理变化，这些变化会影响营养素的可利用性和需求。特别是，居住在养老院的老年人的维生素 D、钴胺素和叶酸状况往往被认为是至关重要的。然而，目前还缺乏研究调查健康和活跃的居家老年人的这些营养素状况。

方法

本横断面研究旨在评估维生素 D 的状况，基于血清 25-羟胆钙化醇[25-(OH)D]浓度、钴胺素基于全钴胺素（holoTC）浓度和叶酸基于红细胞（RBC）叶酸浓度，研究对象为未补充的、健康和活跃的德国居家 70 岁以上老年人（n=134，平均±SD：75.8±4.5 岁）。膳食摄入量通过 3 天的食物回忆来评估。研究于 2021 年 3 月至 11 月期间进行（在 COVID-19 大流行期间）。

结果

平均 25-(OH)D 浓度较高，为 85.1±26.0 nmol/L，而大多数女性（92%）和男性（94%）的 25-(OH)D 浓度≥50 nmol/L。不到 10%的男性和女性 25-(OH)D 浓度<50 nmol/L。平均 holoTC 浓度为 88.9±33.7 pmol/L（女性为 94.8±34.6 pmol/L，男性为 73.6±25.6 pmol/L）。只有 8%的女性存在钴胺素缺乏症（holoTC<50 pmol/L），而男性的这一比例为 22%。平均 RBC 叶酸浓度为 831±244 nmol/L，叶酸缺乏症的患病率为 10%。线性回归分析表明，只有叶酸当量摄入量与相关营养素状态标志物相关。