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库欣综合征表现为非动脉粥样硬化性心肌梗死和心力衰竭。

Cushing's syndrome presenting as non-atherosclerotic myocardial infarction and heart failure.

机构信息

Department of Cardiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, PR China.

Department of Emergency Medicine, The First School of Clinical Medicine, Southern Medical University, Nanjing, PR China.

出版信息

ESC Heart Fail. 2023 Dec;10(6):3714-3717. doi: 10.1002/ehf2.14548. Epub 2023 Oct 18.

DOI:10.1002/ehf2.14548
PMID:37853945
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10682895/
Abstract

Cushing's syndrome is a rare cause of myocardial infarction and heart failure. Herein, we report a female patient who presented acute myocardial infarction and heart failure with reduced ejection fraction. The patient was found to have hypercortisolism secondary to adrenocortical adenoma and responded well to therapy. This case underlines the effects of hypercortisolism on the cardiovascular system. The clinical presentation of this patient is unique because non-atherosclerotic myocardial infarction is rarely reported in Cushing's syndrome patients.

摘要

库欣综合征是心肌梗死和心力衰竭的罕见病因。本文报告了一例以急性心肌梗死和射血分数降低性心力衰竭为表现的女性患者。该患者被发现存在由肾上腺皮质腺瘤引起的皮质醇增多症，经治疗后病情得到缓解。该病例强调了皮质醇增多症对心血管系统的影响。该患者的临床表现较为独特，因为库欣综合征患者很少发生非动脉粥样硬化性心肌梗死。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e50/10682895/3af145f4ad47/EHF2-10-3714-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e50/10682895/e7c9b9213df1/EHF2-10-3714-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e50/10682895/fc525bea62d0/EHF2-10-3714-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e50/10682895/3af145f4ad47/EHF2-10-3714-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e50/10682895/e7c9b9213df1/EHF2-10-3714-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e50/10682895/fc525bea62d0/EHF2-10-3714-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e50/10682895/3af145f4ad47/EHF2-10-3714-g002.jpg

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引用本文的文献

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JCEM Case Rep. 2025 Feb 10;3(3):luaf024. doi: 10.1210/jcemcr/luaf024. eCollection 2025 Mar.

本文引用的文献

1
Spontaneous Coronary Artery Dissection in a Patient With Cushing's Disease.库欣病患者的自发性冠状动脉夹层
Cureus. 2023 Mar 19;15(3):e36370. doi: 10.7759/cureus.36370. eCollection 2023 Mar.
2
Possible, probable, and certain hypercortisolism: A continuum in the risk of comorbidity.可能的、很可能的和确诊的皮质醇增多症：共病风险的连续谱。
Ann Endocrinol (Paris). 2023 Apr;84(2):272-284. doi: 10.1016/j.ando.2023.01.005. Epub 2023 Feb 1.
3
Cardiac Hypertrophy and Related Dysfunctions in Cushing Syndrome Patients-Literature Review.
库欣综合征患者的心脏肥大及相关功能障碍——文献综述
J Clin Med. 2022 Nov 28;11(23):7035. doi: 10.3390/jcm11237035.
4
Long-term morbidity and mortality in patients with Cushing's syndrome.库欣综合征患者的长期发病率和死亡率。
J Neuroendocrinol. 2022 Aug;34(8):e13113. doi: 10.1111/jne.13113. Epub 2022 Mar 21.
5
Angiotensin II type-1 receptor activation in the adult heart causes blood pressure-independent hypertrophy and cardiac dysfunction.成年心脏中血管紧张素II 1型受体的激活会导致与血压无关的心肌肥大和心脏功能障碍。
Cardiovasc Res. 2009 Feb 15;81(3):592-600. doi: 10.1093/cvr/cvn230. Epub 2008 Aug 14.