Kozan Natalie G, Joshi Mrunmayi, Sicherer Sydnee T, Grasman Jonathan M
Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, United States.
Front Bioeng Biotechnol. 2023 Oct 3;11:1245897. doi: 10.3389/fbioe.2023.1245897. eCollection 2023.
Volumetric muscle loss is a traumatic injury which overwhelms the innate repair mechanisms of skeletal muscle and results in significant loss of muscle functionality. Tissue engineering seeks to regenerate these injuries through implantation of biomaterial scaffolds to encourage endogenous tissue formation and to restore mechanical function. Many types of scaffolds are currently being researched for this purpose. Scaffolds are typically made from either natural, synthetic, or conductive polymers, or any combination therein. A major criterion for the use of scaffolds for skeletal muscle is their porosity, which is essential for myoblast infiltration and myofiber ingrowth. In this review, we summarize the various methods of fabricating porous biomaterial scaffolds for skeletal muscle regeneration, as well as the various types of materials used to make these scaffolds. We provide guidelines for the fabrication of scaffolds based on functional requirements of skeletal muscle tissue, and discuss the general state of the field for skeletal muscle tissue engineering.
容积性肌肉损失是一种创伤性损伤，它超出了骨骼肌的固有修复机制，导致肌肉功能显著丧失。组织工程旨在通过植入生物材料支架来再生这些损伤，以促进内源性组织形成并恢复机械功能。目前正为此目的研究多种类型的支架。支架通常由天然聚合物、合成聚合物、导电聚合物或它们的任何组合制成。用于骨骼肌的支架的一个主要标准是其孔隙率，这对于成肌细胞浸润和肌纤维向内生长至关重要。在本综述中，我们总结了制造用于骨骼肌再生的多孔生物材料支架的各种方法，以及用于制造这些支架的各种类型的材料。我们根据骨骼肌组织的功能要求提供支架制造指南，并讨论骨骼肌组织工程领域的总体状况。
