Ebrat Ebrahim, Hejazian Seyyedeh Mina, Ahmadian Elham, Vahed Sepideh Zununi, Mobasseri Majid, Ardalan Mohammadreza
Kidney Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Curr Diabetes Rev. 2024;20(8):55-59. doi: 10.2174/0115733998245369231009111221.
Diabetic nephropathy (DN) is a common complication of type 2 diabetes (T2D). Chronic inflammation and a combination of environmental and genetic factors are involved in the pathogenesis and development of DN.
This case-control study aimed to determine the relationship between rs7529229 and rs2228145 polymorphisms of the IL-6R gene with the incidence of nephropathy among T2D patients.
Fifty-six diabetic patients with nephropathy and 57 T2D patients without nephropathy were included based on inclusion criteria, along with 150 healthy individuals.
The frequencies of AC and CC genotype distributions of the rs2228145 polymorphism in DN patients were significantly higher than in healthy individuals (24.1 and 9.3% versus 10.7 and 6.7%, respectively, P= 0.02). Moreover, the frequency of allele C was higher in DN patients compared to healthy controls (21.30% 12%, P=0.025). However, genotype distribution and allele frequencies of the rs7529229 IL-6R polymorphism in DN patients were not statistically significant in comparison with diabetic patients and healthy individuals (P> 0.05).
The results showed that the allele and genotype distribution frequencies of rs2228145 IL-6R gene polymorphism in patients with DN were significantly higher than in healthy individuals. Therefore, the presence of this polymorphism may be involved in the development of diabetic nephropathy in this population.
糖尿病肾病（DN）是2型糖尿病（T2D）的常见并发症。慢性炎症以及环境与遗传因素的综合作用参与了DN的发病机制和发展过程。
本病例对照研究旨在确定IL-6R基因的rs7529229和rs2228145多态性与T2D患者肾病发生率之间的关系。
根据纳入标准，纳入56例患有肾病的糖尿病患者、57例无肾病的T2D患者以及150名健康个体。
DN患者中rs2228145多态性的AC和CC基因型分布频率显著高于健康个体（分别为24.1%和9.3%，而健康个体为10.7%和6.7%，P = 0.02）。此外，与健康对照相比，DN患者中C等位基因的频率更高（21.30%对12%，P = 0.025）。然而，与糖尿病患者和健康个体相比，DN患者中rs7529229 IL-6R多态性的基因型分布和等位基因频率无统计学意义（P>0.05）。
结果表明，DN患者中rs2228145 IL-6R基因多态性的等位基因和基因型分布频率显著高于健康个体。因此，这种多态性的存在可能参与了该人群糖尿病肾病的发生发展。
