Ferrante Daniela, Angelini Alessia, Barbiero Fabiano, Barbone Fabio, Bauleo Lisa, Binazzi Alessandra, Bovenzi Massimo, Bruno Caterina, Casotto Veronica, Cernigliaro Achille, Ceppi Marcello, Cervino Daniela, Chellini Elisabetta, Curti Stefania, De Santis Marco, Fazzo Lucia, Fedeli Ugo, Fiorillo Germano, Franchi Alberto, Gangemi Manuela, Giangreco Manuela, Rossi Paolo Giorgi, Girardi Paolo, Luberto Ferdinando, Massari Stefania, Mattioli Stefano, Menegozzo Simona, Merlo Domenico Franco, Michelozzi Paola, Migliore Enrica, Miligi Lucia, Oddone Enrico, Pernetti Roberta, Perticaroli Patrizia, Piro Sara, Addario Sebastiano Pollina, Romeo Elisa, Roncaglia Francesca, Silvestri Stefano, Storchi Cinzia, Zona Amerigo, Magnani Corrado, Marinaccio Alessandro
Department of Translational Medicine, Università del Piemonte Orientale and CPO Piemonte, Novara, Italy.
Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.
Am J Ind Med. 2024 Jan;67(1):31-43. doi: 10.1002/ajim.23546. Epub 2023 Oct 19.
Asbestos is a known human carcinogen and is causally associated with malignant mesothelioma, lung, larynx and ovarian cancers.
Cancer risk was studied among a pool of formerly asbestos-exposed workers in Italy. Fifty-two Italian asbestos cohorts (asbestos-cement, rolling-stock, shipbuilding, and other) were pooled and their mortality follow-up was updated to 2018. Standardized mortality ratios (SMRs) were computed for major causes of death considering duration of exposure and time since first exposure (TSFE), using reference rates by region, age and calendar period.
The study included 63,502 subjects (57,156 men and 6346 women): 40% who were alive, 58% who died (cause known for 92%), and 2% lost to follow-up. Mortality was increased for all causes (SMR: men = 1.04, 95% confidence interval [CI] 1.03-1.05; women = 1.15, 95% CI 1.11-1.18), all malignancies (SMR: men = 1.21, 95% CI 1.18-1.23; women = 1.29, 95% CI 1.22-1.37), pleural and peritoneal malignancies (men: SMR = 10.46, 95% CI 9.86-11.09 and 4.29, 95% CI 3.66-5.00; women: SMR = 27.13, 95% CI 23.29-31.42 and 7.51, 95% CI 5.52-9.98), lung (SMR: men = 1.28, 95% CI 1.24-1.32; women = 1.26, 95% CI 1.02-1.53), and ovarian cancer (SMR = 1.42, 95% CI 1.08-1.84). Pleural cancer mortality increased during the first 40 years of TSFE (latency), reaching a plateau thereafter.
Analyses by time-dependent variables showed that the risk for pleural neoplasms increased with latency and no longer increases at long TSFE, consistent with with asbestos clearance from the lungs. Peritoneal neoplasm risk increased over all observation time.
石棉是一种已知的人类致癌物，与恶性间皮瘤、肺癌、喉癌和卵巢癌存在因果关系。
对意大利一组曾接触石棉的工人的癌症风险进行了研究。将52个意大利石棉队列（石棉水泥、铁路车辆、造船及其他）合并，并将其死亡率随访更新至2018年。考虑暴露持续时间和首次暴露后的时间（TSFE），使用按地区、年龄和日历期划分的参考率，计算主要死因的标准化死亡率（SMR）。
该研究纳入了63502名受试者（57156名男性和6346名女性）：40%存活，58%死亡（92%死因已知），2%失访。所有原因导致的死亡率均升高（SMR：男性=1.04，95%置信区间[CI]1.03 - 1.05；女性=1.15，95%CI 1.11 - 1.18），所有恶性肿瘤（SMR：男性=1.21，95%CI 1.18 - 1.23；女性=1.29，95%CI 1.22 - 1.37），胸膜和腹膜恶性肿瘤（男性：SMR = 10.46，95%CI 9.86 - 11.09和4.29，95%CI 3.66 - 5.00；女性：SMR = 27.13，95%CI 23.29 - 31.42和7.51，95%CI 5.52 - 9.98），肺癌（SMR：男性=1.28，95%CI 1.
