Liao Yile, Gui Yu, Li Qingzhou, An Jun, Wang Dong
School of Basic Medical Sciences, State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Laboratory of Integrative Medicine, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan 610041, China.
Biochim Biophys Acta Rev Cancer. 2023 Nov;1878(6):188998. doi: 10.1016/j.bbcan.2023.188998. Epub 2023 Oct 18.
Gastric cancer (GC) is one of the severe malignancies with high incidence and mortality, especially in Eastern Asian countries. Significant advancements have been made in diagnosing and treating GC over the past few decades, resulting in tremendous improvements in patient survival. In recent years, traditional Chinese medicine (TCM) has garnered considerable attention as an alternative therapeutic approach for GC due to its multicomponent and multitarget characteristics. Consequently, natural products found in TCM have attracted researchers' attention, as growing evidence suggests that these natural products can impede GC progression by regulating various biological processes. Nevertheless, their molecular mechanisms are not systematically uncovered. Here, we review the major signaling pathways involved in GC development. Additionally, clinical GC samples were analyzed. Moreover, the anti-GC effects of natural products, their underlying mechanisms and potential targets were summarized. These summaries are intended to facilitate further relevant research, and accelerate the clinical applications of natural products in GC treatment.
胃癌（GC）是一种发病率和死亡率都很高的严重恶性肿瘤，尤其是在东亚国家。在过去几十年里，胃癌的诊断和治疗取得了重大进展，患者生存率得到了极大提高。近年来，传统中药（TCM）因其多成分、多靶点的特点，作为胃癌的一种替代治疗方法受到了广泛关注。因此，中药中的天然产物引起了研究人员的注意，越来越多的证据表明，这些天然产物可以通过调节各种生物过程来阻碍胃癌的进展。然而，它们的分子机制尚未得到系统揭示。在这里，我们综述了参与胃癌发生发展的主要信号通路。此外，还对临床胃癌样本进行了分析。此外，总结了天然产物的抗胃癌作用、其潜在机制和潜在靶点。这些总结旨在促进进一步的相关研究，并加速天然产物在胃癌治疗中的临床应用。
