College of Life Science, Liaoning University, Shenyang, 110036, China.
Shenyang Key Laboratory of Chronic Disease Occurrence and Nutrition Intervention, College of Life Sciences, Liaoning University, Shenyang, 110036, China.
Anticancer Agents Med Chem. 2023;23(13):1506-1518. doi: 10.2174/1871520623666230407082955.
Gastric cancer is a severe malignant tumor with high morbidity and mortality, which seriously affects people's health. At present, the most common treatment for gastric cancer is chemotherapy. However, chemotherapy is very harmful to the human body, and some of the injuries caused by chemotherapy are irreversible. Natural products have low toxicity and anti-cancer activity, so they are currently widely studied at present. Natural products are a large variety of compounds naturally found in fruits, vegetables, spices, and medicinal plants. It is reported that natural products have different anti-cancer properties. This review has summarized the study of natural products in inducing gastric cancer cell apoptosis, inhibiting gastric cancer cell metastasis, and inhibiting gastric cancer cell proliferation. The relevant references on gastric cancer and natural products were obtained from scientific databases, including Pub- Med, Web of Science, and Science Direct. This paper records dozens of natural products with anti-gastric tumor activity and describes the potential living anti-cancer chemical compounds, their element targets, and their underlying mechanism. This review may lay the foundation for future researchers to treat gastric cancer.
胃癌是一种发病率和死亡率都很高的恶性肿瘤，严重影响人们的健康。目前，胃癌最常见的治疗方法是化疗。然而，化疗对人体有很大的伤害，一些由化疗引起的损伤是不可逆的。天然产物的毒性低，抗癌活性高，因此目前受到广泛研究。天然产物是在水果、蔬菜、香料和药用植物中天然存在的多种化合物。据报道，天然产物具有不同的抗癌特性。本综述总结了天然产物在诱导胃癌细胞凋亡、抑制胃癌细胞转移和抑制胃癌细胞增殖方面的研究。通过科学数据库（包括 Pub- Med、Web of Science 和 Science Direct）获得了关于胃癌和天然产物的相关参考文献。本文记录了具有抗胃癌活性的数十种天然产物，并描述了潜在的具有抗癌活性的化学化合物、它们的元素靶标及其潜在机制。本综述可能为未来研究人员治疗胃癌奠定基础。
