Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran.
Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Eur J Clin Invest. 2024 Feb;54(2):e14109. doi: 10.1111/eci.14109. Epub 2023 Oct 19.
N-3 polyunsaturated fatty acids (PUFAs) supplementation has been reported to have an impact on flow-mediated dilatation (FMD), a conventionally used clinical technique for estimating endothelial dysfunction. However, its proven effects on endothelial function are unclear. This systematic review and meta-analysis were conducted to evaluate the effects of n-3 PUFAs supplementation on FMD of the brachial artery.
This study was performed following the PRISMA guidelines. To identify eligible RCTs, a systematic search was completed in PubMed/Medline, Scopus and Web of Science using relevant keywords. A fixed- or random-effects model was utilized to estimate the weighted mean difference (WMD) and 95% confidence interval (95% CI).
Thirty-two studies (with 35 arms) were included in this meta-analysis, involving 2385 subjects with intervention duration ranging from 4 to 48 weeks. The pooled meta-analysis demonstrated a significant effect of omega-3 on FMD (WMD = 0.8%, 95% CI = 0.3-1.3, p = .001) and heterogeneity was significant (I = 82.5%, p < .001).
We found that n-3 PUFA supplementation improves endothelial function as estimated by flow-mediated dilatation of the brachial artery.
已有研究报道，n-3 多不饱和脂肪酸（PUFAs）补充剂对血流介导的扩张（FMD）有影响，FMD 是一种常用于评估内皮功能障碍的临床技术。然而，其对内皮功能的明确作用尚不清楚。本系统评价和荟萃分析旨在评估 n-3 PUFAs 补充剂对肱动脉 FMD 的影响。
本研究遵循 PRISMA 指南进行。为了确定合格的 RCT，我们在 PubMed/Medline、Scopus 和 Web of Science 中使用相关关键词进行了系统搜索。采用固定或随机效应模型来估计加权均数差（WMD）和 95%置信区间（95%CI）。
荟萃分析共纳入 32 项研究（共 35 个研究组），涉及 2385 名受试者，干预时间从 4 周到 48 周不等。荟萃分析表明，ω-3 对 FMD 有显著影响（WMD=0.8%，95%CI=0.3-1.3，p=0.001），且存在显著异质性（I²=82.5%，p<0.001）。
我们发现 n-3 PUFAs 补充剂可改善肱动脉血流介导的扩张，从而改善内皮功能。
