Sutherland Medical Center, Warsaw, 04-036, Poland.
Institute of Health Sciences, Collegium Medicum, The Jan Kochanowski University, Kielce, 25-317, Poland.
Regen Med. 2022 Oct;17(10):709-718. doi: 10.2217/rme-2022-0047. Epub 2022 Jul 28.
Comparison of the efficacy of conservative treatment methods: epidural GOLDIC serum, epidural steroid injections, manual therapy. A randomized, controlled trial. Three groups, each containing 30 patients. GOLDIC or steroid injections (dexamethasone) epidural versus manual therapy. Assessment: initial assessment and 4 (T1), 12 (T2) and 24 (T3) weeks after the last intervention. Primary outcomes: Pain intensity in numeric rating scale, Oswestry disability index, Zurich claudication questionnaire, EQ-5D-5L questionnaire. GOLDIC has shown the highest mean differences and number of cases with minimal important difference among groups for every primary outcome. GOLDIC therapy could be a new option for the nonoperative, symptomatic treatment of degenerative lumbar spinal stenosis and is not inferior to epidural steroid injections and manual therapy.
硬膜外 GOLDIC 血清、硬膜外皮质类固醇注射、手法治疗。一项随机对照试验。三组，每组 30 例。GOLDIC 或皮质类固醇注射（地塞米松）硬膜外与手法治疗。评估：初始评估和末次干预后 4 周（T1）、12 周（T2）和 24 周（T3）。主要结局：数字评分量表的疼痛强度、Oswestry 残疾指数、苏黎世跛行问卷、EQ-5D-5L 问卷。GOLDIC 在每个主要结局方面均显示出最高的平均差异和最小有意义差异的病例数。GOLDIC 治疗可能是退行性腰椎管狭窄症非手术、对症治疗的新选择，并不逊于硬膜外皮质类固醇注射和手法治疗。
