Health Sciences Center, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
Department of Physical Education, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
Front Immunol. 2023 Oct 4;14:1252506. doi: 10.3389/fimmu.2023.1252506. eCollection 2023.
The aim of this study is to analyze whether immune responses after strenuous exercise are influenced by chronological age and fitness level in physically active healthy men.
Cross-sectional study with a sample of 32 physically active men. Participants were divided into two groups based on chronological age (younger: age 21.8 ± 1.8 vs. older: age 34.6 ± 8.3) and subsequently regrouped and divided based on fitness level (More conditioned: excellent and superior VO2max vs. Less conditioned: VO2max: weak, regular and good). Fitness was classified according to VO2max levels obtained by a treadmill test using a gas analyzer. Before and immediately after the ergospirometry test, blood samples were collected for evaluation of immunological markers: leukocytes, neutrophils, lymphocytes and subpopulations.
Chronological age had a moderate effect on CD3+CD4+ lymphocyte count (effect size: 0.204) and CD4/CD8 ratio (effect size: 0.278), favoring older subjects. The level of physical fitness had no significant effect on the analyzed immunological markers.
Immune responses observed immediately after strenuous exercise may be more dependent on chronological age than on fitness level in healthy, physically active men.
本研究旨在分析在活跃健康的男性中，剧烈运动后的免疫反应是否受年龄和体能水平的影响。
这是一项横断面研究，样本包括 32 名活跃的男性。根据年龄（年轻组：年龄 21.8 ± 1.8 岁；年老组：年龄 34.6 ± 8.3 岁）将参与者分为两组，然后根据体能水平（体能更好组：优秀和上等 VO2max 与体能较差组：VO2max：较弱、常规和良好）重新分组和分组。根据跑步机测试中使用气体分析仪获得的 VO2max 水平对体能进行分类。在进行 ergospirometry 测试之前和之后立即采集血液样本，以评估免疫标志物：白细胞、中性粒细胞、淋巴细胞和亚群。
年龄对 CD3+CD4+淋巴细胞计数（效应量：0.204）和 CD4/CD8 比值（效应量：0.278）有中度影响，有利于年龄较大的受试者。体能水平对分析的免疫标志物没有显著影响。
在活跃健康的男性中，剧烈运动后立即观察到的免疫反应可能更多地取决于年龄，而不是体能水平。
