CNRS, INSERM, IRCAN, Faculty of Medicine, Côte d'Azur University, Nice, France.
Department of Medical Genetics, CHU, FHU Oncoage, Nice, France.
EMBO J. 2021 May 3;40(9):e108164. doi: 10.15252/embj.2021108164. Epub 2021 Apr 20.
Cellular senescence is considered to be a major driver of aging, yet the mechanisms explaining the accumulation of senescent cells during life time remain unclear. In this issue, Lagnado et al (2021) show that neutrophils can trigger the senescence of neighboring cells by transmitting reactive oxygen species (ROS), which they normally produce to fight pathogens. The main genomic targets of the neutrophil-mediated ROS damage are telomeres, supporting an intimate interplay between telomere homeostasis and oxidative stress in senescence and consequently aging.
细胞衰老被认为是衰老的主要驱动因素，但解释一生中衰老细胞积累的机制仍不清楚。在本期杂志中，Lagnado 等人（2021 年）表明，中性粒细胞可以通过传递活性氧（ROS）来触发邻近细胞衰老，而 ROS 是它们抵抗病原体时正常产生的。中性粒细胞介导的 ROS 损伤的主要基因组靶标是端粒，这支持了端粒稳态和衰老及随后的衰老过程中氧化应激之间的密切相互作用。
