中性粒细胞：介导 TelOx 氧化和衰老。
Neutrophils: mediating TelOxidation and senescence.
机构信息
CNRS, INSERM, IRCAN, Faculty of Medicine, Côte d'Azur University, Nice, France.
Department of Medical Genetics, CHU, FHU Oncoage, Nice, France.
出版信息
EMBO J. 2021 May 3;40(9):e108164. doi: 10.15252/embj.2021108164. Epub 2021 Apr 20.
Abstract
Cellular senescence is considered to be a major driver of aging, yet the mechanisms explaining the accumulation of senescent cells during life time remain unclear. In this issue, Lagnado et al (2021) show that neutrophils can trigger the senescence of neighboring cells by transmitting reactive oxygen species (ROS), which they normally produce to fight pathogens. The main genomic targets of the neutrophil-mediated ROS damage are telomeres, supporting an intimate interplay between telomere homeostasis and oxidative stress in senescence and consequently aging.
摘要
细胞衰老被认为是衰老的主要驱动因素，但解释一生中衰老细胞积累的机制仍不清楚。在本期杂志中，Lagnado 等人（2021 年）表明，中性粒细胞可以通过传递活性氧（ROS）来触发邻近细胞衰老，而 ROS 是它们抵抗病原体时正常产生的。中性粒细胞介导的 ROS 损伤的主要基因组靶标是端粒，这支持了端粒稳态和衰老及随后的衰老过程中氧化应激之间的密切相互作用。
相似文献
1
Neutrophils: mediating TelOxidation and senescence.中性粒细胞：介导 TelOx 氧化和衰老。
EMBO J. 2021 May 3;40(9):e108164. doi: 10.15252/embj.2021108164. Epub 2021 Apr 20.
2
Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner.中性粒细胞以依赖 ROS 的方式诱导旁分泌端粒功能障碍和衰老。
EMBO J. 2021 May 3;40(9):e106048. doi: 10.15252/embj.2020106048. Epub 2021 Mar 25.
3
DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?细胞衰老过程中端粒和线粒体中的DNA损伤：它们有关联吗？
Nucleic Acids Res. 2007;35(22):7505-13. doi: 10.1093/nar/gkm893. Epub 2007 Nov 5.
4
The Roles of Mitochondrial Dysfunction and Reactive Oxygen Species in Aging and Senescence.线粒体功能障碍和活性氧在衰老和衰老中的作用。
Curr Mol Med. 2022;22(1):37-49. doi: 10.2174/1566524021666210218112616.
5
Noncoding RNAs Controlling Telomere Homeostasis in Senescence and Aging.非编码 RNA 调控衰老和老化过程中端粒稳态。
Trends Mol Med. 2020 Apr;26(4):422-433. doi: 10.1016/j.molmed.2020.01.010. Epub 2020 Feb 28.
6
Telomeres and Cell Senescence - Size Matters Not.端粒与细胞衰老——大小无足轻重。
EBioMedicine. 2017 Jul;21:14-20. doi: 10.1016/j.ebiom.2017.03.027. Epub 2017 Mar 21.
7
Long-lived post-mitotic cell aging: is a telomere clock at play?长寿的有丝分裂后细胞衰老：端粒钟在起作用吗？
Mech Ageing Dev. 2020 Jul;189:111256. doi: 10.1016/j.mad.2020.111256. Epub 2020 May 4.
8
Angiotensin II-mediated oxidative DNA damage accelerates cellular senescence in cultured human vascular smooth muscle cells via telomere-dependent and independent pathways.血管紧张素II介导的氧化性DNA损伤通过端粒依赖和非依赖途径加速培养的人血管平滑肌细胞衰老。
Circ Res. 2008 Feb 1;102(2):201-8. doi: 10.1161/CIRCRESAHA.107.158626. Epub 2007 Nov 8.
9
[Replicative senescence as a model of aging: the role of oxidative stress and telomere shortening--an overview].[复制性衰老作为衰老模型：氧化应激和端粒缩短的作用——综述]
Z Gerontol Geriatr. 1999 Apr;32(2):69-75. doi: 10.1007/s003910050086.
10
Telomeres: beacons of autocrine and paracrine DNA damage during skin aging.端粒：皮肤衰老过程中自分泌和旁分泌 DNA 损伤的信标。
Cell Cycle. 2020 Mar;19(5):532-540. doi: 10.1080/15384101.2020.1728016. Epub 2020 Feb 16.
引用本文的文献
1
Involvement of NRF2 and AMPK signaling in aging and progeria: a digest.NRF2和AMPK信号通路在衰老和早衰中的作用：综述
Redox Biol. 2025 Jul 21;85:103782. doi: 10.1016/j.redox.2025.103782.
2
OGG1 and MUTYH repair activities promote telomeric 8-oxoguanine induced senescence in human fibroblasts.OGG1和MUTYH修复活性促进人成纤维细胞中端粒8-氧代鸟嘌呤诱导的衰老。
Nat Commun. 2025 Jan 21;16(1):893. doi: 10.1038/s41467-024-55638-4.
3
Therapy-induced senescence through the redox lens.通过氧化还原的视角看治疗诱导的衰老。
Redox Biol. 2024 Aug;74:103228. doi: 10.1016/j.redox.2024.103228. Epub 2024 Jun 6.
4
Telomeres: Dysfunction, Maintenance, Aging and Cancer.端粒：功能障碍、维护、衰老和癌症。
Aging Dis. 2023 Nov 29;15(6):2595-2631. doi: 10.14336/AD.2023.1128.
5
Telomeres as hotspots for innate immunity and inflammation.端粒作为先天免疫和炎症的热点。
DNA Repair (Amst). 2024 Jan;133:103591. doi: 10.1016/j.dnarep.2023.103591. Epub 2023 Nov 5.
6
NRF2 signaling pathway and telomere length in aging and age-related diseases.NRF2 信号通路与端粒长度在衰老及其相关疾病中的作用。
Mol Cell Biochem. 2024 Oct;479(10):2597-2613. doi: 10.1007/s11010-023-04878-x. Epub 2023 Nov 2.
7
Influence of age and fitness level on immune responses of T and NK cells in healthy physically active subjects after strenuous aerobic exercise: a cross-sectional study.剧烈有氧运动后，健康活跃的受试者的 T 和 NK 细胞的免疫反应受年龄和健康水平的影响：一项横断面研究。
Front Immunol. 2023 Oct 4;14:1252506. doi: 10.3389/fimmu.2023.1252506. eCollection 2023.
8
Oxidative Stress-Induced Cellular Senescence: Is Labile Iron the Connecting Link?氧化应激诱导的细胞衰老：不稳定铁是其中的联系纽带吗？
Antioxidants (Basel). 2023 Jun 10;12(6):1250. doi: 10.3390/antiox12061250.
9
Telomere length declines with age, but relates to immune function independent of age in a wild passerine.端粒长度随年龄增长而缩短，但在一种野生雀形目鸟类中，端粒长度与免疫功能相关，且与年龄无关。
R Soc Open Sci. 2022 Apr 27;9(4):212012. doi: 10.1098/rsos.212012. eCollection 2022 Apr.
10
Telomere dysfunction in ageing and age-related diseases.端粒功能障碍与衰老和衰老相关疾病。
Nat Cell Biol. 2022 Feb;24(2):135-147. doi: 10.1038/s41556-022-00842-x. Epub 2022 Feb 14.
本文引用的文献
1
Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner.中性粒细胞以依赖 ROS 的方式诱导旁分泌端粒功能障碍和衰老。
EMBO J. 2021 May 3;40(9):e106048. doi: 10.15252/embj.2020106048. Epub 2021 Mar 25.
2
Mitochondrial function in skeletal myofibers is controlled by a TRF2-SIRT3 axis over lifetime.线粒体在骨骼肌纤维中的功能受 TRF2-SIRT3 轴的终生控制。
Aging Cell. 2020 Mar;19(3):e13097. doi: 10.1111/acel.13097. Epub 2020 Jan 28.
3
Cellular Senescence: Defining a Path Forward.细胞衰老：定义前进的道路。
Cell. 2019 Oct 31;179(4):813-827. doi: 10.1016/j.cell.2019.10.005.
4
Neutrophils escort circulating tumour cells to enable cell cycle progression.中性粒细胞护送循环肿瘤细胞以促进细胞周期进程。
Nature. 2019 Feb;566(7745):553-557. doi: 10.1038/s41586-019-0915-y. Epub 2019 Feb 6.
5
Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice.中性粒细胞胞外诱捕网在炎症期间产生，可唤醒小鼠体内休眠的癌细胞。
Science. 2018 Sep 28;361(6409). doi: 10.1126/science.aao4227.
6
The impact of oxidative DNA damage and stress on telomere homeostasis.氧化 DNA 损伤和应激对端粒稳态的影响。
Mech Ageing Dev. 2019 Jan;177:37-45. doi: 10.1016/j.mad.2018.03.013. Epub 2018 Mar 28.
7
Peroxiredoxin 1 Protects Telomeres from Oxidative Damage and Preserves Telomeric DNA for Extension by Telomerase.过氧化物酶1保护端粒免受氧化损伤，并保留端粒DNA以供端粒酶延长。
Cell Rep. 2016 Dec 20;17(12):3107-3114. doi: 10.1016/j.celrep.2016.11.071.
8
Circulating TNF and mitochondrial DNA are major determinants of neutrophil phenotype in the advanced-age, frail elderly.循环肿瘤坏死因子和线粒体DNA是高龄体弱老年人中性粒细胞表型的主要决定因素。
Mol Immunol. 2015 May;65(1):148-56. doi: 10.1016/j.molimm.2015.01.015. Epub 2015 Feb 5.
9
Telomere dysfunction induces metabolic and mitochondrial compromise.端粒功能障碍导致代谢和线粒体功能受损。
Nature. 2011 Feb 17;470(7334):359-65. doi: 10.1038/nature09787. Epub 2011 Feb 9.
10
Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress.端粒酶并不抵消端粒缩短，而是在氧化应激下保护线粒体功能。
J Cell Sci. 2008 Apr 1;121(Pt 7):1046-53. doi: 10.1242/jcs.019372. Epub 2008 Mar 11.
Zotero 插件