减重手术后患者与非手术对照组身体成分变量的比较。
Comparison of Body Composition Variables between Post-Bariatric Surgery Patients and Non-Operative Controls.
作者信息
Tangjittrong Sirinrat, Udomsawaengsup Suthep, Boonchaya-Anant Patchaya
机构信息
Department of Internal Medicine, Rayong Hospital, Rayong, Thailand.
Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
出版信息
Clin Med Insights Endocrinol Diabetes. 2023 Oct 17;16:11795514231206731. doi: 10.1177/11795514231206731. eCollection 2023.
BACKGROUND
Since bariatric surgery results in massive weight loss, it may be associated with a disproportionate decrease in lean body mass.
OBJECTIVE
To evaluate body composition in post-bariatric surgery patients who had a successful weight loss at 12 months (>50% excess weight loss) with comparisons to healthy controls who were matched for age, sex and BMI.
METHODS
This is an observational analytic study using data from post-bariatric surgery patients who had laparoscopic Roux-en-Y gastric bypass (RYGB) or laparoscopic sleeve gastrectomy (SG) at King Chulalongkorn Memorial Hospital. Patients who had percentage excessive weight loss (%EWL) >50% and achieved a BMI of <30 kg/m within 12 months after the surgery were included. Non-operative healthy controls matched for sex, age, and BMI (1:1) were recruited. The 12-month post-bariatric surgery BMI was used to match the BMI of the control subjects. A single bioelectrical impedance analysis (BIA) (Inbody 770) machine was used for the entire study.
RESULTS
Sixty participants were included in this study. There are 30 post-bariatric surgery patients (female n = 19, male n = 11) and 30 non-operative controls (female n = 19, male n = 11). The 12-month post-bariatric surgery patients had lower percentage of body fat (PBF) (30.6% vs 35.9%, -value .001) and trunk fat mass (10.3 vs 12.4 kg, -value .04) than non-operative controls. The 12-month post-bariatric surgery patients also were found to have more soft lean mass (SLM) (47.7 vs 39.9 kg, -value .001), fat free mass (FFM) (51.1 vs 42.3 kg, -value .001), skeletal muscle mass (SMM) (27.5 vs 23 kg, -value .003), and trunk lean mass (21.2 vs 19 kg, -value .02).
CONCLUSION
Despite the significant reductions in all body composition variables in post-bariatric surgery patients at 12-month follow-up, both fat free mass and skeletal muscle mass were found to be higher in the surgical patients compared to the control group.
CLINICAL TRIALS
Thai Clinical Trials Registry, https://thaiclinicaltrials.org/ID:TCTR20200223003.
背景
由于减肥手术会导致大量体重减轻，可能与去脂体重不成比例的减少有关。
目的
评估减肥手术后12个月体重成功减轻（超重减轻>50%）的患者的身体成分，并与年龄、性别和体重指数相匹配的健康对照者进行比较。
方法
这是一项观察性分析研究，使用朱拉隆功国王纪念医院接受腹腔镜Roux-en-Y胃旁路术（RYGB）或腹腔镜袖状胃切除术（SG）的减肥手术患者的数据。纳入术后12个月内超重减轻百分比（%EWL）>50%且体重指数<30kg/m²的患者。招募性别、年龄和体重指数相匹配（1:1）的非手术健康对照者。使用减肥手术后12个月的体重指数来匹配对照者的体重指数。整个研究使用一台生物电阻抗分析（BIA）（Inbody 770）机器。
结果
本研究纳入60名参与者。其中有30名减肥手术后患者（女性19名，男性11名）和30名非手术对照者（女性19名，男性11名）。减肥手术后12个月的患者体脂百分比（PBF）低于非手术对照者（30.6%对35.9%，P值0.001），躯干脂肪量也低于非手术对照者（10.3对12.4kg，P值0.04）。还发现减肥手术后12个月的患者有更多的软去脂体重（SLM）（47.7对39.9kg，P值0.001）、无脂肪量（FFM）（51.1对42.3kg，P值0.001）、骨骼肌量（SMM）（27.5对23kg，P值0.003）和躯干去脂体重（21.2对19kg，P值0.02）。
结论
尽管减肥手术后12个月随访时所有身体成分变量均显著降低，但手术患者的无脂肪量和骨骼肌量均高于对照组。
临床试验
泰国临床试验注册中心，https://thaiclinicaltrials.org/ID:TCTR20200223003 。
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