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基孔肯雅病毒扰乱 Wnt/β-连环蛋白信号通路以实现有效的病毒感染。

Chikungunya virus perturbs the Wnt/β-catenin signaling pathway for efficient viral infection.

机构信息

Institute of Life Sciences , Bhubaneswar, India.

Regional Centre for Biotechnology , Faridabad, India.

出版信息

J Virol. 2023 Nov 30;97(11):e0143023. doi: 10.1128/jvi.01430-23. Epub 2023 Oct 20.

DOI:10.1128/jvi.01430-23
PMID:37861335
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10688348/
Abstract

Being obligate parasites, viruses use various host cell machineries in effectively replicating their genome, along with virus-encoded enzymes. In order to carry out infection and pathogenesis, viruses are known to manipulate fundamental cellular processes in cells and interfere with host gene expression. Several viruses interact with the cellular proteins involved in the Wnt/β-catenin pathway; however, reports regarding the involvement of protein components of the Wnt/β-catenin pathway in Chikungunya virus (CHIKV) infection are scarce. Additionally, there are currently no remedies or vaccines available for CHIKV. This is the first study to report that modulation of the Wnt/β-catenin pathway is crucial for effective CHIKV infection. These investigations deepen the understanding of the underlying mechanisms of CHIKV infection and offer new avenue for developing effective countermeasures to efficiently manage CHIKV infection.

摘要

作为专性寄生生物，病毒在有效地复制其基因组的同时，会利用各种宿主细胞机制和病毒编码的酶。为了进行感染和发病，病毒已知会操纵细胞中的基本细胞过程，并干扰宿主基因表达。一些病毒与参与 Wnt/β-catenin 途径的细胞蛋白相互作用；然而，关于 Wnt/β-catenin 途径的蛋白成分在基孔肯雅热病毒（CHIKV）感染中的参与的报告很少。此外，目前尚无针对 CHIKV 的治疗方法或疫苗。这是第一项报道调节 Wnt/β-catenin 途径对有效 CHIKV 感染至关重要的研究。这些研究加深了对 CHIKV 感染潜在机制的理解，并为开发有效对策来有效管理 CHIKV 感染提供了新的途径。

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