编码新城疫病毒基质蛋白的基因的核苷酸序列。
Nucleotide sequence of the gene encoding the matrix protein of Newcastle disease virus.
作者信息
Chambers P, Millar N S, Platt S G, Emmerson P T
出版信息
Nucleic Acids Res. 1986 Nov 25;14(22):9051-61. doi: 10.1093/nar/14.22.9051.
Abstract
The nucleotide sequence of the gene encoding the matrix (M) protein of the Beaudette C strain of Newcastle disease virus (NDV) has been determined from overlapping cDNA clones. Control sequences typical of paramyxovirus mRNA start and polyadenylation signals have been identified. Assuming that the M gene starts and finishes at these sequences, the M gene is 1241 nucleotides long and encodes one long open reading frame of 364 amino acids, corresponding to a polypeptide of molecular weight 39605, in good agreement with estimates from SDS gels. The M protein has an amino acid sequence that is both hydrophobic and highly basic. The NDV M protein has sequence homologies to the M proteins of Sendai, measles, canine distemper and respiratory syncytial viruses.
摘要
已通过重叠cDNA克隆确定了新城疫病毒（NDV）博德特C株编码基质（M）蛋白的基因的核苷酸序列。已鉴定出副粘病毒mRNA起始和聚腺苷酸化信号典型的控制序列。假设M基因在这些序列处起始和终止，M基因长度为1241个核苷酸，编码一个364个氨基酸的长开放阅读框，对应分子量为39605的多肽，与SDS凝胶的估计结果高度一致。M蛋白的氨基酸序列既具有疏水性又具有高碱性。NDV M蛋白与仙台病毒、麻疹病毒、犬瘟热病毒和呼吸道合胞病毒的M蛋白具有序列同源性。
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