Kuzmina I V, Ovchinnikova N V, Tolpygo S M
P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia.
Bull Exp Biol Med. 2023 Sep;175(5):608-611. doi: 10.1007/s10517-023-05910-2. Epub 2023 Oct 20.
Trypsin is mainly regarded as a digestive enzyme, but there is evidence that activation of protease-activated receptor-2 (PAR-2) leads to behavioral changes. There are no data on trypsin activity in the serum of animals under conditions of thirst and starvation in the available literature. In our experiments, water deprivation led to a significant (p⩽0.05) increase in trypsin activity in rats, and food deprivation led to its decrease in comparison with controls (free access to water and food). After deprived rats received water and food, a decrease in trypsin activity was observed in both experimental groups. Changes in trypsin activity under conditions of water or food deprivation and after satiation were accompanied by shifts in some biochemical parameters of the bloods. Under conditions of metabolic stress (starvation and thirst), opposite changes in trypsin activity seem to indicate its participation in the mechanisms of adequate restructuring of metabolism and maintenance of vital processes in the body.
胰蛋白酶主要被视为一种消化酶，但有证据表明蛋白酶激活受体-2（PAR-2）的激活会导致行为变化。现有文献中没有关于动物在口渴和饥饿条件下血清中胰蛋白酶活性的数据。在我们的实验中，与对照组（可自由获取水和食物）相比，缺水导致大鼠胰蛋白酶活性显著（p⩽0.05）升高，禁食导致其降低。在缺水和禁食的大鼠获得水和食物后，两个实验组的胰蛋白酶活性均降低。在缺水或禁食条件下以及饱腹感后胰蛋白酶活性的变化伴随着血液某些生化参数的改变。在代谢应激（饥饿和口渴）条件下，胰蛋白酶活性的相反变化似乎表明其参与了机体代谢适当重组和维持生命过程的机制。
