Kuzmina I V, Tolpygo S M, Shoibonov B B, Ovchinnikova N V
Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, Moscow, Russia.
Bull Exp Biol Med. 2025 Jan;178(3):319-322. doi: 10.1007/s10517-025-06329-7. Epub 2025 Feb 13.
We have previously demonstrated multidirectional changes in trypsin activity and some serum biochemical parameters in rats under conditions of water and food deprivation with following satiation. In the present study, administration of soybean trypsin inhibitor (STI) to animals subjected to water and food deprivation caused a moderate decrease in trypsin activity and an increase in the serum concentration of total protein, which attested to deceleration of protein metabolism. Significant changes in the content of cholesterol and triglycerides against the background of STI administration were also found indicating intensification of lipid and energy metabolism. These findings suggest that STI prevents disturbances of metabolic processes in the body under conditions of water and food deprivation. However, the peculiarities of STI influence on metabolic processes require further study.
我们之前已经证明，在禁食禁水随后再饱食的条件下，大鼠的胰蛋白酶活性和一些血清生化参数会发生多向变化。在本研究中，给禁食禁水的动物施用大豆胰蛋白酶抑制剂（STI）会导致胰蛋白酶活性适度降低，血清总蛋白浓度升高，这证明蛋白质代谢减缓。在施用STI的背景下，还发现胆固醇和甘油三酯含量有显著变化，表明脂质和能量代谢增强。这些发现表明，STI可防止禁食禁水条件下体内代谢过程的紊乱。然而，STI对代谢过程影响的特殊性需要进一步研究。
