Arboviral Diseases Branch, Division of Vector-Borne Infectious Diseases, U.S. Centers for Disease Control and Prevention, 3156 Rampart Road, Fort Collins, CO 80521, USA.
J Med Entomol. 2023 Nov 14;60(6):1230-1241. doi: 10.1093/jme/tjad058.
Cache Valley virus (CVV) is a mosquito-borne virus in the genus Orthobunyavirus (Bunyavirales: Peribunyaviridae) that has been identified as a teratogen in ruminants causing fetal death and severe malformations during epizootics in the U.S. CVV has recently emerged as a viral pathogen causing severe disease in humans. Despite its emergence as a public health and agricultural concern, CVV has yet to be significantly studied by the scientific community. Limited information exists on CVV's geographic distribution, ecological cycle, seroprevalence in humans and animals, and spectrum of disease, including its potential as a human teratogen. Here, we present what is known of CVV's virology, ecology, and clinical disease in ruminants and humans. We discuss the current diagnostic techniques available and highlight gaps in our current knowledge and considerations for future research.
卡谷病毒（CVV）是一种虫媒病毒，属于正布尼亚病毒目（Bunyavirales：Peribunyaviridae），在美国的流行期间，被确定为反刍动物的致畸物，导致胎儿死亡和严重畸形。CVV 最近已成为一种病毒性病原体，导致人类严重疾病。尽管它已成为公共卫生和农业关注的焦点，但科学界对 CVV 的研究还很有限。关于 CVV 的地理分布、生态循环、人和动物的血清流行率以及疾病谱，包括其作为人类致畸物的潜力，信息有限。在这里，我们介绍了已知的 CVV 病毒学、生态学和反刍动物及人类的临床疾病。我们讨论了现有的诊断技术，并强调了我们当前知识中的空白和对未来研究的考虑。
