Fuentes V O, Hunt W B, Crossland J
Psychopharmacology (Berl). 1978 Sep 15;59(1):65-9. doi: 10.1007/BF00428032.
A method for the chronical administration of morphine by the oral route is discussed and compared with the production of physical dependence to morphine by injection. The method recommends the administration of Morphine HCl dissolved in a 45% sucrose syrup and given orally for 4 weeks. The initial concentration of morphine in the syrup was 1 mg/ml and was increased weekly up to 4 mg/ml at the end of the experiment. This procedure rendered the animals physically dependent on morphine as observed by drug withdrawal, when abstinence symptoms were easily identified.
本文讨论了一种口服吗啡的长期给药方法，并将其与注射吗啡产生身体依赖性的情况进行了比较。该方法建议将盐酸吗啡溶解在45%的蔗糖糖浆中口服给药，持续4周。糖浆中吗啡的初始浓度为1毫克/毫升，在实验结束时每周增加，直至达到4毫克/毫升。通过药物戒断观察发现，这种给药程序使动物对吗啡产生了身体依赖性，此时戒断症状很容易识别。
