Khavari K A, Peters T C, Baity P L, Wilson A S
Pharmacol Biochem Behav. 1975 Nov-Dec;3(6):1093-6. doi: 10.1016/0091-3057(75)90022-2.
We are reporting on conditions (without forced drinking or premedications) where rats voluntarily drink high quantities of sucrose-morphine solutions in preference to water. The volume ingested is inversely related to the morphine concentration in the liquid. The morphine antagonist, nalorphine, produced a clear set of opiate withdrawal signs in these (voluntarily) morphine-drinking rats. The severity of withdrawal signs was a function of the amount of ingested morphine. The present finding is the first report to show that rats ingest high quantities of sucrose-morphine without premedication or forced hydration procedures.
我们正在报告大鼠在（无强制饮水或预处理）条件下自愿大量饮用蔗糖 - 吗啡溶液而非水的情况。摄入的液体量与液体中的吗啡浓度呈负相关。吗啡拮抗剂烯丙吗啡在这些（自愿）饮用吗啡的大鼠中产生了一系列明显的阿片类戒断症状。戒断症状的严重程度取决于摄入吗啡的量。目前的发现是首次表明大鼠在无预处理或强制补水程序的情况下大量摄入蔗糖 - 吗啡的报告。
