Numan R
Pharmacol Biochem Behav. 1986 Nov;25(5):1111-5. doi: 10.1016/0091-3057(86)90094-8.
Male, hooded rats were made physically dependent upon ethanol using intravenous infusions. Following this induction procedure, physical dependence was maintained, but now a tone (CS) was associated with ethanol infusions (US) that reduced withdrawal distress. A pretest-posttest, counterbalanced, repeated measures design was used to assess the effects of three treatments (ethanol, tone, none) on withdrawal reactions (withdrawal signs, body temperature, open-field activity) measured under blind conditions. Only the ethanol treatment reduced withdrawal distress, suggesting that classical conditioning did not occur. The results are discussed in terms of recent conditioning theories of drug responses, and the potential role of stress in these reactions.
雄性有帽大鼠通过静脉输注使其对乙醇产生身体依赖性。在这个诱导程序之后，身体依赖性得以维持，但现在一种音调（条件刺激）与能减轻戒断痛苦的乙醇输注（非条件刺激）相关联。采用了一种前测 - 后测、平衡、重复测量设计，以评估三种处理（乙醇、音调、无处理）对在盲态条件下测量的戒断反应（戒断体征、体温、旷场活动）的影响。只有乙醇处理减轻了戒断痛苦，这表明经典条件作用并未发生。根据最近的药物反应条件作用理论以及应激在这些反应中的潜在作用对结果进行了讨论。
