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妊娠和产后首发系统性红斑狼疮合并弥漫性肺泡出血的异常表现:病例报告。

Abnormal presentation of pregnancy and postpartum initial-onset systemic lupus erythematosus combined with diffuse alveolar hemorrhage: A case report.

机构信息

Department of Rheumatology and Immunology, Anqing Medical Centre, Anhui Medical University, Anqing, China.

Department of Rheumatology and Immunology, Wannan Medical College, Wuhu, China.

出版信息

Lupus. 2023 Nov;32(13):1579-1582. doi: 10.1177/09612033231210060. Epub 2023 Oct 20.

DOI:10.1177/09612033231210060
PMID:37864322
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10666484/
Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease that most commonly occurs in women of childbearing age. However, cases of SLE with abnormal pregnancy as the initial manifestation, involving the development of diffuse alveolar hemorrhage (DAH), have rarely been reported. Herein, we report the case of a young woman who underwent a cesarean section for fetal distress and growth restriction at 35 + 1 weeks' gestation. Following discharge, she experienced progressive worsening of anemia and chest tightness, which was later diagnosed as SLE complicated by DAH.

摘要

系统性红斑狼疮(SLE)是一种自身免疫性疾病,最常发生在育龄期妇女中。然而,以异常妊娠为首发表现、合并弥漫性肺泡出血(DAH)的 SLE 病例很少见。在此,我们报告了一例 35+1 周妊娠因胎儿窘迫和生长受限而行剖宫产术的年轻女性。出院后,她逐渐出现贫血和胸闷加重,后被诊断为 SLE 合并 DAH。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2792/10666484/ac6d64e7b880/10.1177_09612033231210060-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2792/10666484/ac6d64e7b880/10.1177_09612033231210060-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2792/10666484/ac6d64e7b880/10.1177_09612033231210060-fig1.jpg

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本文引用的文献

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Semin Arthritis Rheum. 2023 Feb;58:152143. doi: 10.1016/j.semarthrit.2022.152143. Epub 2022 Nov 25.
2
Pregnancy-related complications in systemic lupus erythematosus.系统性红斑狼疮的妊娠相关并发症。
J Autoimmun. 2022 Oct;132:102864. doi: 10.1016/j.jaut.2022.102864. Epub 2022 Jul 21.
3
Humanized Mouse Models of Systemic Lupus Erythematosus: Opportunities and Challenges.
人类系统性红斑狼疮小鼠模型:机遇与挑战。
Front Immunol. 2022 Jan 18;12:816956. doi: 10.3389/fimmu.2021.816956. eCollection 2021.
4
Clinical features of new-onset systemic lupus erythematosus during pregnancy in Central China: a retrospective study of 68 pregnancies.华中地区妊娠中新发系统性红斑狼疮的临床特征:68 例妊娠的回顾性研究。
Clin Rheumatol. 2021 Jun;40(6):2121-2131. doi: 10.1007/s10067-020-05452-2. Epub 2020 Oct 16.
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Lupus-Induced Vasculitis and Multiple Organ Dysfunction Syndrome as the First Presentation of Systemic Lupus Erythematosus (SLE) in Pregnancy.狼疮诱导的血管炎和多器官功能障碍综合征作为妊娠期系统性红斑狼疮(SLE)的首发表现
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