碘介导的吲哚的C2,3-H氨基杂芳基化反应

Iodine-Mediated C2,3-H Aminoheteroarylation of Indoles.

作者信息

Dai Maoyi, Zhang Yingying, Zhang Xiaoxiang, Wang Ruiyi, Wei Wanxing, Zhang Zhuan, Liang Taoyuan

机构信息

School of Chemistry and Chemical Engineering, Guangxi University, Nanning, Guangxi 530004, P. R. China.

Guangxi Key Laboratory of Electrochemical Energy Materials, Nanning, Guangxi 530004, P. R. China.

出版信息

J Org Chem. 2023 Nov 3;88(21):15106-15117. doi: 10.1021/acs.joc.3c01591. Epub 2023 Oct 21.

DOI:10.1021/acs.joc.3c01591

PMID:37864558

Abstract

A metal-free one-pot oxidative cross-dehydrogenation coupling reaction for the formation of C-N/C-C bonds at the C2,3-positions of indoles with azoles and quinoxalinones has been developed. The proposed method has several notable features, including metal-free catalysis, the use of N-H free indoles as substrates, ease of operation, mild reaction conditions, and compatibility with a wide range of substrates.

摘要

已开发出一种无金属一锅法氧化交叉脱氢偶联反应，用于在吲哚的C2,3位与唑类和喹喔啉酮形成C-N/C-C键。该方法具有几个显著特点，包括无金属催化、使用无N-H的吲哚作为底物、操作简便、反应条件温和以及与多种底物具有兼容性。